Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 16/20 | 0.77 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20713751 | 0.92 | KLKB1 (0.77) | KLKB1USP30GFERHRH4HRH3 | |
| SCHEMBL20713772 | 0.91 | KLKB1 (0.64) | KLKB1USP30ROCK2 | |
| SCHEMBL20713753 | 0.90 | KLKB1 (0.62) | KLKB1USP30GFERHRH4HRH3 | |
| SCHEMBL20705180 | 0.87 | KLKB1 (1.00) | KLKB1USP30 | |
| SCHEMBL20713784 | 0.86 | KLKB1 (0.58) | KLKB1 | |
| SCHEMBL20713648 | 0.84 | KLKB1 (0.64) | KLKB1USP30GFERHRH4HRH3 | |
| SCHEMBL20713763 | 0.84 | KLKB1 (0.64) | KLKB1USP30GFERHRH4HRH3 | |
| SCHEMBL22277317 | 0.84 | KLKB1 (0.65) | KLKB1USP30ROCK2 | |
| SCHEMBL20705067 | 0.82 | KLKB1 (0.59) | KLKB1GFERHRH4HRH3 | |
| SCHEMBL20705069 | 0.82 | KLKB1 (0.59) | KLKB1GFERHRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019028362-A1 | INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | DYAX CORP. (US) | 2019-02-07 | — | — | WO | disclosed |