Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 2/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.35 |
| ▸ | PLA2G4A | P47712 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9881129 | 0.96 | CHEK2 (0.39) | CHEK2MAPTALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL24303517 | 0.95 | PLA2G2A (0.40) | CHEK2MAPTALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL22195781 | 0.95 | PLA2G2A (0.40) | CHEK2MAPTALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL16812258 | 0.95 | PLA2G2A (0.40) | CHEK2MAPTALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL17616865 | 0.95 | PLA2G2A (0.40) | CHEK2MAPTALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL18565661 | 0.94 | MAPT (0.41) | CHEK2MAPTALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL15294004 | 0.94 | PLA2G2A (0.41) | CHEK2MAPTALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL20634237 | 0.94 | PLA2G2A (0.41) | CHEK2MAPTALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL23318323 | 0.94 | PLA2G2A (0.41) | CHEK2MAPTALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL22737690 | 0.93 | CHEK2 (0.41) | CHEK2MAPTALDH1A1NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190044071-A1 | CARBAZOLES WITH TWO DIBENZOFURAN OR DIBENZOTHIOPHENE SUBSTITUENTS | MERCK PATENT GMBH (DE) | 2019-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190044071-A1 | CARBAZOLES WITH TWO DIBENZOFURAN OR DIBENZOTHIOPHENE SUBSTITUENTS | BRD3, BRPF3, DDT | CHEK2 1190/4885MAPT 1546/4885ALDH1A1 610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.