Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | OXTR | P30559 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.32 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.32 |
| ▸ | ITGAL | P20701 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6069296 | 1.00 | NISCH (0.39) | NISCHDAOSCN5AALDH1A1HPGD | |
| SCHEMBL2069021 | 1.00 | NISCH (0.39) | NISCHDAOSCN5AALDH1A1HPGD | |
| SCHEMBL7166201 | 0.78 | NISCH (0.38) | NISCHDAOSCN5AALDH1A1HPGD | |
| SCHEMBL7166205 | 0.78 | NISCH (0.38) | NISCHDAOSCN5AALDH1A1HPGD | |
| SCHEMBL6068629 | 0.76 | CYP19A1 (0.35) | ALDH1A1CA2HTR1ASLC6A2 | |
| SCHEMBL6068624 | 0.76 | CYP19A1 (0.35) | ALDH1A1CA2HTR1ASLC6A2 | |
| SCHEMBL18365855 | 0.75 | ABCG2 (0.50) | NISCHCA2ABCG2ITGB2ICAM1 | |
| SCHEMBL6068846 | 0.73 | MAP3K14 (0.35) | NISCHSLC6A2 | |
| SCHEMBL6068844 | 0.73 | MAP3K14 (0.35) | NISCHSLC6A2 | |
| SCHEMBL29395105 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902381-B2 | Synthesising method and benzoxathiepine intermediates | PIERRE FABRE MEDICAMENT (FR) | 2011-03-08 | — | — | US | claimed |
| US-20080234499-A1 | Synthesising Method and Benzoxathiepine Intermediates | PIERRE FABRE MEDICAMENT (FR) | 2008-09-25 | — | — | US | claimed |
| EP-1735297-B1 | SYNTHESISING METHOD AND BENZOXATHIEPINE INTERMEDIATES | PF MEDICAMENT (FR) | 2007-10-03 | — | — | EP | claimed |
| EP-1735297-A1 | SYNTHESISING METHOD AND BENZOXATHIEPINE INTERMEDIATES | PIERRE FABRE MEDICAMENT (FR) | 2006-12-27 | — | — | EP | claimed |
| WO-2005103027-A1 | SYNTHESISING METHOD AND BENZOXATHIEPINE INTERMEDIATES | PIERRE FABRE MEDICAMENT (FR) | 2005-11-03 | — | — | WO | claimed |
| US-7982054-B2 | Process for the synthesis of N-[3-[(2-methoxyphenyl] sulfanyl] -2-methylpropyl] -3,4-dihydro-2H-1,5-benzoxathiepin-3-amine | PIERRE FABRE MEDICAMENT (FR) | 2011-07-19 | — | — | US | disclosed |
| US-7982054-B2 | Process for the synthesis of N-[3-[(2-methoxyphenyl] sulfanyl] -2-methylpropyl] -3,4-dihydro-2H-1,5-benzoxathiepin-3-amine | PIERRE FABRE MEDICAMENT (FR) | 2011-07-19 | — | — | US | disclosed |
| US-7982054-B2 | Process for the synthesis of N-[3-[(2-methoxyphenyl] sulfanyl] -2-methylpropyl] -3,4-dihydro-2H-1,5-benzoxathiepin-3-amine | PIERRE FABRE MEDICAMENT (FR) | 2011-07-19 | — | — | US | disclosed |
| US-7902381-B2 | Synthesising method and benzoxathiepine intermediates | PIERRE FABRE MEDICAMENT (FR) | 2011-03-08 | — | — | US | disclosed |
| US-7902381-B2 | Synthesising method and benzoxathiepine intermediates | PIERRE FABRE MEDICAMENT (FR) | 2011-03-08 | — | — | US | disclosed |
| EP-2089374-B1 | METHOD FOR THE SYNTHESIS OF N- [3- [ (2-METHOXYPHENYL) SULFANYL] -2- METHYLPROPYL]-3,4-DIHYDRO-2H-1,5-BENZOXATHIEPIN-3-AMINE | PF MEDICAMENT (FR) | 2010-08-04 | — | — | EP | disclosed |
| EP-2089374-B1 | METHOD FOR THE SYNTHESIS OF N- [3- [ (2-METHOXYPHENYL) SULFANYL] -2- METHYLPROPYL]-3,4-DIHYDRO-2H-1,5-BENZOXATHIEPIN-3-AMINE | PF MEDICAMENT (FR) | 2010-08-04 | — | — | EP | disclosed |
| US-20080234499-A1 | Synthesising Method and Benzoxathiepine Intermediates | PIERRE FABRE MEDICAMENT (FR) | 2008-09-25 | — | — | US | disclosed |
| WO-2008068403-A2 | METHOD FOR THE SYNTHESIS OF N- [3- [ (2-METHOXYPHÉNYL) SULFANYL] -2- METHYLPROPYL] -3,4-DIHYDRO-2H-1,5-BENZOXATHIEPIN-3-AMINE<0} | PIERRE FABRE MEDICAMENT (FR) | 2008-06-12 | — | — | WO | disclosed |
| EP-1735297-B1 | SYNTHESISING METHOD AND BENZOXATHIEPINE INTERMEDIATES | PF MEDICAMENT (FR) | 2007-10-03 | — | — | EP | disclosed |
| US-7109234-B2 | Benzoxathiepine derivatives and their use as medicines | PIERRE FABRE MEDICAMENT (FR) | 2006-09-19 | — | — | US | disclosed |
| EP-1370547-B1 | BENZOAXATHIEPIN DERIVATIVES AND THEIR USE AS MEDICINES | PF MEDICAMENT (FR) | 2004-09-15 | — | — | EP | disclosed |
| US-20040127552-A1 | Benzoaxathiepin derivatives and their use as medicines | PIERRE FABRE MEDICAMENT (FR) | 2004-07-01 | — | — | US | disclosed |
| EP-1370547-A1 | BENZOAXATHIEPIN DERIVATIVES AND THEIR USE AS MEDICINES | PIERRE FABRE MEDICAMENT (FR) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002081464-A1 | BENZOAXATHIEPIN DERIVATIVES AND THEIR USE AS MEDICINES | PIERRE FABRE MEDICAMENT (FR) | 2002-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127552-A1 | Benzoaxathiepin derivatives and their use as medicines | CYP4A11, CYP3A4, CYP4F11 | NISCH 1540/4885DAO 288/4885SCN5A 2574/4885 |
| US-20080234499-A1 | Synthesising Method and Benzoxathiepine Intermediates | CYP2F1, CYP2E1, CBR1 | NISCH 1261/4885DAO 244/4885SCN5A 2273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.