Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 15/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 14/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 2/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20715420 | 0.82 | HTR3A (0.52) | HRH1CYP2D6CHRM1KCNH2HTR3A | |
| SCHEMBL20715421 | 0.82 | HTR3A (0.53) | HRH1CYP2D6CHRM1KCNH2HTR3A | |
| SCHEMBL22726492 | 0.77 | MCHR1 (0.50) | HRH1CYP2D6CHRM1KCNH2HTR3A | |
| SCHEMBL20715426 | 0.73 | HRH1 (0.58) | HRH1CYP2D6CHRM1KCNH2CYP3A4 | |
| SCHEMBL4422612 | 0.72 | SOS1 (0.58) | HRH1CYP2D6CHRM1KCNH2CYP3A4 | |
| SCHEMBL4443670 | 0.71 | SOS1 (0.52) | HRH1CYP2D6CHRM1KCNH2HTR3A | |
| SCHEMBL20919806 | 0.68 | HRH1 (0.54) | HRH1CYP2D6CHRM1KCNH2HTR3A | |
| SCHEMBL20919807 | 0.68 | HRH1 (0.54) | HRH1CYP2D6CHRM1KCNH2HTR3A | |
| SCHEMBL20715424 | 0.67 | HRH1 (0.60) | HRH1CYP2D6CHRM1KCNH2HTR3A | |
| SCHEMBL31633134 | 0.67 | HRH1 (0.57) | HRH1CYP2D6CHRM1KCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019028308-A1 | BENZIMIDAZOLES AND AZA-BENZIMIDAZOLES, AND METHODS OF USE THEREOF | GOLDFINCH BIO, INC. (US) | 2019-02-07 | — | — | WO | disclosed |