Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 7/20 | 0.56 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.56 |
| ▸ | HPGDS | O60760 | 5/20 | 0.56 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2070459 | 0.91 | HPGDS (0.64) | HCRTR1HCRTR2HPGDSUSP30MAP4K4 | |
| SCHEMBL1365780 | 0.90 | HCRTR1 (0.56) | HCRTR1HCRTR2HPGDSMAP4K4PDE10A | |
| SCHEMBL2070316 | 0.89 | HCRTR1 (0.53) | HCRTR1HCRTR2HPGDSUSP30MAP4K4 | |
| SCHEMBL2070314 | 0.89 | HCRTR1 (0.53) | HCRTR1HCRTR2HPGDSUSP30MAP4K4 | |
| SCHEMBL2070318 | 0.89 | HCRTR1 (0.53) | HCRTR1HCRTR2HPGDSUSP30MAP4K4 | |
| SCHEMBL14191078 | 0.83 | HPGDS (0.67) | HPGDSUSP30MAP4K4DRD2DRD4 | |
| SCHEMBL2071576 | 0.83 | HPGDS (0.54) | HCRTR1HCRTR2HPGDSUSP30MAP4K4 | |
| SCHEMBL12776510 | 0.81 | HPGDS (0.64) | HPGDSUSP30MAP4K4 | |
| SCHEMBL2073644 | 0.80 | HPGDS (0.68) | HPGDSUSP30DRD2DRD4 | |
| SCHEMBL1543340 | 0.80 | HPGDS (0.74) | HPGDSUSP30MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902373-B2 | asthma; for treating prostaglandin D2 mediated diseases; e.g. 6-(3-fluorophenyl)-N-[1-(1-methyl-1H-tetrazol-5-yl)piperidin-4-yl]nicotinamide | PFIZER INC (US) | 2011-03-08 | — | — | US | disclosed |
| US-20080146569-A1 | Nicotinamide Derivatives | PFIZER INC. | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146569-A1 | Nicotinamide Derivatives | NNT, NAMPT, NADK | HCRTR1 2126/4885HCRTR2 2788/4885HPGDS 984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.