Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 9/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.40 |
| ▸ | SMO | Q99835 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2071903 | 0.91 | HPGDS (0.61) | HPGDSALDH1A1POLBUSP30MAP4K4 | |
| SCHEMBL2073136 | 0.90 | HPGDS (0.57) | HPGDSALDH1A1POLBUSP30MAP4K4 | |
| SCHEMBL2073082 | 0.86 | HPGDS (0.57) | HPGDSALDH1A1POLBUSP30GABRA5 | |
| SCHEMBL2070062 | 0.86 | HPGDS (0.63) | HPGDSALDH1A1POLBUSP30MAP4K4 | |
| SCHEMBL2070308 | 0.84 | HPGDS (0.60) | HPGDSALDH1A1POLBUSP30DRD2 | |
| SCHEMBL5061048 | 0.83 | HPGDS (0.61) | HPGDSALDH1A1POLBUSP30MAP4K4 | |
| SCHEMBL2073193 | 0.82 | HPGDS (0.57) | HPGDSALDH1A1POLBUSP30MAP4K4 | |
| SCHEMBL2071036 | 0.82 | HPGDS (0.61) | HPGDSALDH1A1POLBUSP30MAP4K4 | |
| SCHEMBL2070154 | 0.81 | HPGDS (0.58) | HPGDSALDH1A1POLBUSP30MAP4K4 | |
| SCHEMBL2071686 | 0.79 | HPGDS (0.65) | HPGDSUSP30GABRA5DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902373-B2 | asthma; for treating prostaglandin D2 mediated diseases; e.g. 6-(3-fluorophenyl)-N-[1-(1-methyl-1H-tetrazol-5-yl)piperidin-4-yl]nicotinamide | PFIZER INC (US) | 2011-03-08 | — | — | US | disclosed |