Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 5/20 | 0.67 |
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.49 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.48 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2072096 | 0.99 | HPGDS (0.66) | HPGDSGRM5MAP4K4GABRA5KLKB1 | |
| SCHEMBL1543109 | 0.93 | HPGDS (0.60) | HPGDSGRM5MAP4K4GABRA5KLKB1 | |
| SCHEMBL1543105 | 0.93 | HPGDS (0.60) | HPGDSGRM5MAP4K4GABRA5KLKB1 | |
| SCHEMBL1543340 | 0.92 | HPGDS (0.74) | HPGDSGRM5MAP4K4GABRA5USP30 | |
| SCHEMBL1543648 | 0.90 | HPGDS (0.71) | HPGDSGRM5MAP4K4GABRA5 | |
| SCHEMBL13240659 | 0.90 | HPGDS (0.56) | HPGDSGRM5MAP4K4GABRA5KLKB1 | |
| Hydrochloric Acid SCHEMBL3096065 | 0.89 | HPGDS (0.56) | HPGDSGRM5MAP4K4GABRA5KLKB1 | |
| Hydrochloric Acid SCHEMBL3096068 | 0.89 | HPGDS (0.56) | HPGDSGRM5MAP4K4GABRA5KLKB1 | |
| Hydrochloric Acid SCHEMBL3096074 | 0.89 | HPGDS (0.56) | HPGDSGRM5MAP4K4GABRA5KLKB1 | |
| SCHEMBL1543463 | 0.89 | HPGDS (0.70) | HPGDSGRM5MAP4K4GABRA5USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902373-B2 | asthma; for treating prostaglandin D2 mediated diseases; e.g. 6-(3-fluorophenyl)-N-[1-(1-methyl-1H-tetrazol-5-yl)piperidin-4-yl]nicotinamide | PFIZER INC (US) | 2011-03-08 | — | — | US | disclosed |
| EP-2129660-A2 | NICOTINAMIDE DERIVATIVES AS INHIBITORS OF H-PGDS AND THEIR USE FOR TREATING PROSTAGLANDIN D2 MEDIATED DISEASES | Pfizer Products Inc. (US) | 2009-12-09 | — | — | EP | disclosed |
| WO-2008075172-A2 | NICOTINAMIDE DERIVATIVES AS INHIBITORS OF H-PGDS AND THEIR USE FOR TREATING PROSTAGLANDIN D2 MEDIATED DISEASES | PFIZER PRODUCTS INC. (US) | 2008-06-26 | — | — | WO | disclosed |
| US-20080146569-A1 | Nicotinamide Derivatives | PFIZER INC. | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146569-A1 | Nicotinamide Derivatives | NNT, NAMPT, NADK | HPGDS 984/4885GRM5 3073/4885MAP4K4 1602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.