Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14669634 | 0.79 | CYP3A4 (0.32) | TSHRALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL13746699 | 0.71 | TSHR (0.32) | TSHR | |
| SCHEMBL4807998 | 0.71 | PGD (0.43) | TSHRALDH1A1 | |
| SCHEMBL4806982 | 0.71 | PGD (0.43) | TSHRALDH1A1 | |
| SCHEMBL5681121 | 0.71 | TSHR (0.32) | TSHR | |
| SCHEMBL2436838 | 0.71 | — | — | |
| SCHEMBL14064557 | 0.71 | TSHR (0.36) | TSHRCYP3A4CYP2C19 | |
| SCHEMBL13839654 | 0.71 | — | — | |
| SCHEMBL14064560 | 0.71 | TSHR (0.36) | TSHRCYP3A4CYP2C19 | |
| SCHEMBL3447297 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7893268-B2 | Epithiolone analogues | UNIVERSITY OF TOLEDO (US) | 2011-02-22 | — | — | US | disclosed |
| US-20090258904-A1 | Epithiolone Analogues | UNIVERSITY OF TOLEDO | 2009-10-15 | — | — | US | disclosed |
| WO-2007015929-A2 | EPOTHILONE ANALOGUES | UNIVERSITY OF TOLEDO (US) | 2007-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258904-A1 | Epithiolone Analogues | ESRRB, ESR2, ESRRA | TSHR 2808/4885ALDH1A1 2265/4885CYP3A4 722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.