PGD

6-phosphogluconate dehydrogenase, decarboxylating · P52209 · PGD on Sugi Atlas →

4,298 patent compounds predicted against PGD, 2,290 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL158903	0.68	5/20
SCHEMBL2134967	0.68	5/20
SCHEMBL5791056	0.55	5/20
SCHEMBL65097	0.55	5/20
SCHEMBL80335	0.53	5/20
SCHEMBL4404352	0.53	5/20
Phosphoric Acid (SCHEMBL5917775)	0.52	5/20
SCHEMBL704407	0.50	5/20
Mannose 6-Phosphate (SCHEMBL5583695)	0.42	5/20
Epigalocatechin Gallate (SCHEMBL35258)	1.00	4/20
Epicatechin Gallate (SCHEMBL39046)	1.00	4/20
Epicatechin Gallate (SCHEMBL39047)	1.00	4/20
Gallocatechin Gallate (SCHEMBL49461)	1.00	4/20
Catechin Gallate (SCHEMBL145289)	1.00	4/20
Epigalocatechin Gallate (SCHEMBL161547)	1.00	4/20
Epigalocatechin Gallate (SCHEMBL1853219)	1.00	4/20
SCHEMBL2219243	1.00	4/20
Epicatechin Gallate (SCHEMBL4545330)	1.00	4/20
Epicatechin Gallate (SCHEMBL4639313)	1.00	4/20
(-)-Catechingallate (SCHEMBL4639342)	1.00	4/20

Clinical trials — most relevant to PGD by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Triheptanoin Treatment Trial for Patients With Long-chain Fatty Acid Beta-oxidation Defects	PHASE3	WITHDRAWN
Pyronaridine Artesunate (3:1) in Children and Adults With Acute Plasmodium Vivax Malaria	PHASE3	COMPLETED
Acetylcarnitine and Insulin Sensitivity	PHASE2	COMPLETED
Changes in Breast Cancer Biomarkers Using Synergistic Prostaglandin Inhibitors	PHASE1/PHASE2	COMPLETED
Efficacy and Safety of the Treatment of Pyruvate Dehydrogenase Deficiency Patients With Glycerol Phenylbutyrate (RAVICTI)	PHASE2	RECRUITING
The Effect of Triheptanoin on Fatty Acid Oxidation and Exercise Tolerance in Patients With Glycogenoses	PHASE2	COMPLETED
Hydroxychloroquine Administration for Reduction of Pexophagy	PHASE2	COMPLETED
Use of Phenylbutyrate Therapy for Patients With Pyruvate Dehydrogenase Complex Deficiency.	PHASE2	COMPLETED
Dynamic PET/CT Evaluated the Response of Neoadjuvant Anti-PD1 Combination With Chemotherapy for Ⅱa-Ⅲb NSCLC	PHASE2	UNKNOWN
UCB Transplant of Inherited Metabolic Diseases With Administration of Intrathecal UCB Derived Oligodendrocyte-Like Cells	PHASE1	RECRUITING
Treatment Development for Glucose Transporter Type I Deficiency Syndrome (G1D)	PHASE1	COMPLETED
Experimental Malaria Infection of Healthy Malaria-Naive Adults by Mosquito Bite With the Genetically Modified Plasmodium Falciparum NF54/iGP3 GAP	PHASE1	NOT_YET_RECRUITING
McArdle Disease Treatment by Ketogenic Diet	nan	COMPLETED
Natural History and Advanced Genetic Study of Pyruvate Dehydrogenase Complex Deficiencies	nan	RECRUITING
GSD VI and GSD IX Natural History	nan	RECRUITING
The Safety and Efficacy Study of RiaGev in Healthy Adults	nan	UNKNOWN
Systemic Inflammatory Response: Thiamine and Magnesium Status (Sir TaM Study)	nan	COMPLETED
Cardiac Manifestation and Inherited Metabolic Diseases	nan	COMPLETED
Metabolic Remodeling in Pulmonary Arterial Hypertension (PAH)	nan	COMPLETED
Tolerability and Efficacy of L-Serine in Patients With GRIN-related Encephalopathy	nan	UNKNOWN
Unrelated Donor BMT for Treatment of Patients With PGK Deficiency	nan	COMPLETED
MyRareDiet A Novel Diet Tracking Tool	nan	NOT_YET_RECRUITING
Fatty Acid Oxidation Defects and Insulin Sensitivity	nan	COMPLETED
IMPROV (Improving the Radical Cure of Vivax Malaria)	nan	COMPLETED
Biomarkers in Exhaled Breath Condensates in Acute Lung Injury: Early Detection and Outcome Predictors	nan	UNKNOWN
MNGIE Natural History Study	nan	RECRUITING
Pyruvate Kinase Deficiency Global Longitudinal Registry	nan	ACTIVE_NOT_RECRUITING
Thiamine As An Adjuvant Therapy For Hyperlactatemia In Septic Shock Patients	nan	UNKNOWN
Circadian Brown Adipose Tissue Metabolism	nan	COMPLETED
Biomarker for Glycogen Storage Diseases (BioGlycogen)	nan	WITHDRAWN

Related proteins — ESM-2 sequence neighbours (a PGD binder may also engage these)

Protein	Name	Similarity
P85968	—	1.000	P85968 →
Q17761	—	1.000	Q17761 →
P53319	—	1.000	P53319 →
P00349	—	1.000	P00349 →
P38720	—	1.000	P38720 →
Q8TA03	—	1.000	Q8TA03 →
Q9DCD0	—	1.000	Q9DCD0 →
P41570	—	1.000	P41570 →
P41575	—	1.000	P41575 →
P41573	—	0.999	P41573 →
Q9LI00	—	0.998	Q9LI00 →
P41582	—	0.998	P41582 →
P41577	—	0.998	P41577 →
P41583	—	0.997	P41583 →
P41581	—	0.997	P41581 →
Q2R480	—	0.997	Q2R480 →
P00350	—	0.997	P00350 →
P41572	—	0.996	P41572 →
Q94KU1	—	0.996	Q94KU1 →
P41578	—	0.996	P41578 →
P78812	—	0.995	P78812 →
O60037	—	0.995	O60037 →
Q9FWA3	—	0.995	Q9FWA3 →
Q6G954	—	0.993	Q6G954 →
P63335	—	0.993	P63335 →
P41574	—	0.992	P41574 →
Q9CHU6	—	0.992	Q9CHU6 →
P52208	—	0.992	P52208 →
P70718	—	0.992	P70718 →
P37754	—	0.992	P37754 →