⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3787095 | 0.76 | — | — | |
| SCHEMBL6780045 | 0.68 | — | — | |
| SCHEMBL84864 | 0.67 | NPSR1 (0.50) | — | |
| SCHEMBL21863396 | 0.63 | CYP11B1 (0.45) | — | |
| SCHEMBL20903335 | 0.63 | KDM4E (0.37) | — | |
| SCHEMBL977789 | 0.61 | HDAC1 (0.36) | — | |
| SCHEMBL20721556 | 0.60 | KDM4E (0.36) | — | |
| SCHEMBL21863416 | 0.60 | FLT3 (0.48) | — | |
| SCHEMBL21936861 | 0.60 | KDM4E (0.40) | — | |
| SCHEMBL973664 | 0.60 | ALDH1A1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111527099-B | Selective inhibitors of protein arginine methyltransferase 5 (PRMT 5) | 普莱鲁德疗法有限公司 | 2024-03-22 | — | — | CN | claimed |
| EP-3665179-B1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS INC (US) | 2021-06-09 | — | — | EP | claimed |
| US-10570140-B2 | Selective inhibitors of protein arginine methyltransferase 5 (PRMT5) | PRELUDE THERAPEUTICS INCORPORATED (US) | 2020-02-25 | — | — | US | claimed |
| US-20190048014-A1 | Selective Inhibitors Of Protein Arginine Methyltransferase 5 (PRMT5) | PRELUDE THERAPEUTICS INCORPORATED | 2019-02-14 | — | — | US | claimed |
| CN-111527099-B | Selective inhibitors of protein arginine methyltransferase 5 (PRMT 5) | 普莱鲁德疗法有限公司 | 2024-03-22 | — | — | CN | disclosed |
| US-20220152072-A1 | Selective Inhibitors Of Protein Arginine Methyltransferase 5 (PRMT5) | PRELUDE THERAPEUTICS, INCORPORATED | 2022-05-19 | — | — | US | disclosed |
| US-20220153747-A1 | Selective Inhibitors Of Protein Arginine Methytransterase 5 (PRMT5) | PRELUDE THERAPEUTICS, INCORPORATED | 2022-05-19 | — | — | US | disclosed |
| EP-3952874-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 | Prelude Therapeutics, Incorporated (US) | 2022-02-16 | — | — | EP | disclosed |
| EP-3939986-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | Prelude Therapeutics, Incorporated (US) | 2022-01-19 | — | — | EP | disclosed |
| US-11208416-B2 | Selective inhibitors of protein arginine methytransterase 5 (PRMT5) | PRELUDE THERAPEUTICS INCORPORATED (US) | 2021-12-28 | — | — | US | disclosed |
| US-11078205-B2 | Selective inhibitors of protein arginine methlytransferase 5 (PRMT5) | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2021-08-03 | — | — | US | disclosed |
| EP-3665179-B1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS INC (US) | 2021-06-09 | — | — | EP | disclosed |
| US-20200361946-A1 | Selective Inhibitors Of Protein Arginine Methytransterase 5 (PRMT5) | PRELUDE THERAPEUTICS INC (US) | 2020-11-19 | — | — | US | disclosed |
| WO-2020206289-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2020-10-08 | — | — | WO | disclosed |
| EP-3665179-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | Prelude Therapeutics, Incorporated (US) | 2020-06-17 | — | — | EP | disclosed |
| US-20200148692-A1 | Selective Inhibitors Of Protein Arginine Methytransterase 5 (PRMT5) | PRELUDE THERAPEUTICS INC (US) | 2020-05-14 | — | — | US | disclosed |
| US-10570140-B2 | Selective inhibitors of protein arginine methyltransferase 5 (PRMT5) | PRELUDE THERAPEUTICS INCORPORATED (US) | 2020-02-25 | — | — | US | disclosed |
| US-20190048014-A1 | Selective Inhibitors Of Protein Arginine Methyltransferase 5 (PRMT5) | PRELUDE THERAPEUTICS INCORPORATED | 2019-02-14 | — | — | US | disclosed |
| WO-2019032859-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2019-02-14 | — | — | WO | disclosed |