Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.73 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.73 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.73 |
| ▸ | MAOA | P21397 | 4/20 | 0.52 |
| ▸ | MAOB | P27338 | 4/20 | 0.52 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ADH5 | P11766 | 2/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4413259 | 1.00 | CYP11B1 (0.73) | CYP11B1CYP11B2CYP19A1MAOAMAOB | |
| SCHEMBL2071832 | 0.85 | CYP11B1 (1.00) | CYP11B1CYP11B2CYP19A1MAOAMAOB | |
| Trifluoromethanesulfonic Acid SCHEMBL23277132 | 0.85 | CYP11B1 (0.71) | CYP11B1CYP11B2CYP19A1MAOAMAOB | |
| Trifluoroacetic Acid SCHEMBL2073231 | 0.84 | CYP3A4 (0.70) | CYP3A4MEN1ALOX15TSHRKMT2A | |
| SCHEMBL9812373 | 0.77 | ADH5 (0.66) | CYP11B1CYP11B2CYP19A1MAOAMAOB | |
| SCHEMBL9812342 | 0.76 | ADH5 (0.64) | CYP11B1CYP11B2CYP19A1MAOAMAOB | |
| SCHEMBL28274864 | 0.71 | CYP11B1 (0.71) | CYP11B1CYP11B2CYP19A1MAOAMAOB | |
| SCHEMBL13045131 | 0.70 | CYP19A1 (1.00) | CYP11B1CYP11B2CYP19A1MAOAMAOB | |
| Anthracene SCHEMBL1558998 | 0.70 | CES1 (0.50) | MEN1KMT2AIDO1 | |
| Naphthalene SCHEMBL29443947 | 0.70 | CES1 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863294-B2 | Heterocycle derivatives as histone deacetylase (HDAC) inhibitors | INSTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-01-04 | — | — | US | disclosed |
| US-20090048228-A1 | Heterocycle Derivatives As Histone Deacetylase (Hdac) Inhibitors | MSD ITALIA S.R.L. (IT) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048228-A1 | Heterocycle Derivatives As Histone Deacetylase (Hdac) Inhibitors | HDAC1, HDAC5, HDAC11 | CYP11B1 567/4885CYP11B2 979/4885CYP19A1 1818/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.