Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20505096 | 1.00 | MAPT (0.44) | MAPTLMNAGAAALDH1A1MEN1 | |
| SCHEMBL7008952 | 0.83 | LRRK2 (0.45) | MAPTLMNAGAAALDH1A1MEN1 | |
| SCHEMBL240371 | 0.79 | MAPT (0.43) | MAPTLMNAGAAALDH1A1MEN1 | |
| SCHEMBL554552 | 0.77 | MAPT (0.46) | MAPTLMNAGAAALDH1A1MEN1 | |
| SCHEMBL2203198 | 0.74 | LRRK2 (0.50) | MAPTLMNAGAAALDH1A1MEN1 | |
| SCHEMBL7980321 | 0.74 | MAPT (0.56) | MAPTLMNAGAAALDH1A1KDM4E | |
| SCHEMBL21296775 | 0.73 | GSK3B (0.52) | MAPTLMNAGAAALDH1A1MEN1 | |
| SCHEMBL555451 | 0.73 | GSK3B (0.52) | MAPTLMNAGAAALDH1A1MEN1 | |
| SCHEMBL370447 | 0.73 | LRRK2 (0.48) | MAPTLMNAGAAALDH1A1MEN1 | |
| SCHEMBL3153578 | 0.73 | ALDH1A1 (0.56) | MAPTLMNAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4303 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023213965-A1 | INHIBITORS OF CDK8 AND CDK19 | UNIVERSITY OF DUNDEE (GB) | 2023-11-09 | — | — | WO | claimed |
| WO-2023158795-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | ACCENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | claimed |
| US-20230142803-A1 | NATURAL KILLER CELLS AND ILC3 CELLS AND USES THEREOF | CELULARITY INC. (US) | 2023-05-11 | — | — | US | claimed |
| EP-4055014-A1 | PYRROLIDINE AND PIPERIDINE COMPOUNDS | Yuhan Corporation (KR) | 2022-09-14 | — | — | EP | claimed |
| CN-108349953-B | Pesticidal compositions and methods | 孟山都技术公司 | 2022-06-17 | — | — | CN | claimed |
| WO-2022094079-A1 | METHODS OF TREATING CYSTIC FIBROSIS | THE TRUSTEES OF DARTMOUTH COLLEGE (US) | 2022-05-05 | — | — | WO | claimed |
| US-20210379033-A1 | METHODS OF TREATING CANCER WITH ARYL HYDROCARBON RECEPTOR ANTAGONISTS | EDIGENE BIOTECHNOLOGY, INC. (CN) | 2021-12-09 | — | — | US | claimed |
| CN-113710675-A | Fused 9-hydroxy-1, 8-dioxo-1, 3,4, 8-tetrahydro-2H-pyrido [1,2-a ] pyrazine-7-carboxamides as HIV integrase inhibitors | 亚历山大·瓦西里耶维奇·伊瓦切恩科 | 2021-11-26 | — | — | CN | claimed |
| CN-107660205-B | Heterocyclic compounds as LSD1 inhibitors | 因赛特公司 | 2021-08-27 | — | — | CN | claimed |
| CN-113301897-A | Methods of treating cancer with arene receptor antagonists | 美真达治疗公司 | 2021-08-24 | — | — | CN | claimed |
| EP-0099303-A2 | Benzothiopyranopyridinones and their salts, their preparation and use as medicaments, and compositions containing them | ROUSSEL-UCLAF (FR) | 1984-01-25 | — | — | EP | claimed |
| EP-0076530-A2 | Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-04-13 | — | — | EP | claimed |
| EP-0068544-A2 | Novel N-aryl-piperazinealkanamides | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-01-05 | — | — | EP | claimed |
| EP-0007605-B1 | A PROCESS FOR INVERTING THE CONFIGURATION IN OPTICALLY ACTIVE COMPOUNDS AND OPTICALLY ACTIVE INTERMEDIATE COMPOUNDS AND THEIR SALTS REQUIRED THEREFOR | CIBA-GEIGY AG (CH) | 1982-09-15 | — | — | EP | claimed |
| EP-0014928-B1 | PIPERIDINOPROPYL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1982-05-05 | — | — | EP | claimed |
| EP-0005318-B1 | N-HETEROCYCLYL-4-PIPERIDINAMINES, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, INTERMEDIATES THEREFOR, AND METHOD FOR THE PREPARATION OF THE INTERMEDIATES | JANSSEN PHARMACEUTICA N.V. (BE) | 1982-01-06 | — | — | EP | claimed |
| US-4219559-A | N-Heterocyclyl-4-piperidinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1980-08-26 | — | — | US | claimed |
| EP-0007605-A1 | A process for inverting the configuration in optically active compounds and optically active intermediate compounds and their salts required therefor | CIBA-GEIGY AG (CH) | 1980-02-06 | — | — | EP | claimed |
| EP-0005318-A1 | N-Heterocyclyl-4-piperidinamines, methods for their preparation, pharmaceutical compositions comprising them, intermediates therefor, and method for the preparation of the intermediates | JANSSEN PHARMACEUTICA N.V. (BE) | 1979-11-14 | — | — | EP | claimed |
| US-4166853-A | Antihypertensive 7-trifluoromethyl-4-aminoquinolones | THE UPJOHN COMPANY (US) | 1979-09-04 | — | — | US | claimed |