Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20725845 | 0.94 | ATIC (0.60) | ATICROCK2 | |
| SCHEMBL20725765 | 0.93 | ATIC (0.59) | ATICROCK2 | |
| SCHEMBL20725872 | 0.92 | ATIC (0.69) | ATICROCK2 | |
| SCHEMBL20725851 | 0.92 | ATIC (0.69) | ATICROCK2 | |
| SCHEMBL20725768 | 0.90 | ATIC (0.56) | ATICROCK2 | |
| SCHEMBL20725749 | 0.89 | ATIC (0.69) | ATICROCK2 | |
| SCHEMBL20725712 | 0.86 | ATIC (0.58) | ATICROCK2 | |
| SCHEMBL20725764 | 0.84 | ATIC (0.69) | ATICROCK2 | |
| SCHEMBL20725838 | 0.83 | ATIC (0.51) | ATICROCK2 | |
| SCHEMBL17801571 | 0.82 | ATIC (0.85) | ATICROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3227279-B1 | 1-OXO-1,2-DIHYDROISOQUINOLIN-7-YL-(5-SUBSTITUTED-THIOPHEN-2-YL)-SULFONAMIDE COMPOUNDS, FORMULATIONS CONTAINING THOSE COMPOUNDS, AND THEIR USE AS AICARFT INHIBITORS IN THE TREATMENT OF CANCERS | LILLY CO ELI (US) | 2019-02-13 | — | — | EP | disclosed |