Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 6/20 | 0.72 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.72 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | NOS2 | P35228 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2073934 | 0.90 | SLC6A4 (0.72) | SLC6A4SLC6A2CYP2D6KCNH2SLC6A3 | |
| SCHEMBL12933709 | 0.85 | SLC6A4 (0.72) | SLC6A4SLC6A2CYP2D6KCNH2SLC6A3 | |
| SCHEMBL2074218 | 0.84 | SLC6A4 (1.00) | SLC6A4SLC6A2CYP2D6KCNH2SLC6A3 | |
| SCHEMBL2072655 | 0.83 | SLC6A4 (0.69) | SLC6A4SLC6A2CYP2D6KCNH2SLC6A3 | |
| SCHEMBL12933675 | 0.82 | SLC6A4 (0.67) | SLC6A4SLC6A2CYP2D6KCNH2SLC6A3 | |
| SCHEMBL2075069 | 0.82 | SLC6A4 (0.67) | SLC6A4SLC6A2CYP2D6KCNH2SLC6A3 | |
| SCHEMBL27663362 | 0.80 | KMT2A (0.50) | SLC6A4SLC6A2CYP2D6KCNH2HTR2A | |
| SCHEMBL3232638 | 0.78 | SLC6A4 (0.72) | SLC6A4SLC6A2CYP2D6KCNH2SLC6A3 | |
| SCHEMBL2074801 | 0.78 | SLC6A4 (0.72) | SLC6A4SLC6A2CYP2D6KCNH2SLC6A3 | |
| SCHEMBL2075066 | 0.77 | SLC6A4 (0.67) | SLC6A4SLC6A2CYP2D6KCNH2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863305-B2 | 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitors | ROCHE PALO ALTO LLC (US) | 2011-01-04 | — | — | US | disclosed |
| US-7863305-B2 | 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitors | ROCHE PALO ALTO LLC (US) | 2011-01-04 | — | — | US | disclosed |
| US-7863305-B2 | 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitors | ROCHE PALO ALTO LLC (US) | 2011-01-04 | — | — | US | disclosed |