Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.39 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | USP8 | P40818 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20726481 | 0.90 | ERBB2 (0.40) | CHEK1KIF11MAPTALDH1A1USP8 | |
| SCHEMBL20726482 | 0.89 | ERBB2 (0.42) | CHEK1KIF11MAPTALDH1A1USP8 | |
| SCHEMBL20726412 | 0.82 | PRKDC (0.43) | CHEK1PDGFRBPRKDCPIK3CDPIK3CA | |
| SCHEMBL20726519 | 0.81 | CHRM5 (0.34) | CHEK1 | |
| SCHEMBL20726369 | 0.79 | KDR (0.40) | CHEK1PDGFRBCSF1RABL1RPS6KA3 | |
| SCHEMBL20726443 | 0.77 | APP (0.44) | CHEK1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL20726434 | 0.77 | ERBB2 (0.39) | CHEK1MAPTALDH1A1PRKAB2PRKAG1 | |
| SCHEMBL20726485 | 0.76 | ERCC1 (0.40) | CHEK1MAPTKDM4EALDH1A1 | |
| SCHEMBL20726349 | 0.76 | ERBB2 (0.41) | CHEK1MAPTALDH1A1PRKAB2PRKAG1 | |
| SCHEMBL20726454 | 0.76 | PDE3B (0.46) | CHEK1KIF11MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083611-B1 | OXINDOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE IN THE TREATMENT OF AMPK-RELATED DISEASES | SANOFI SA (FR) | 2019-02-13 | — | — | EP | disclosed |