Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2072710 | 0.86 | HPGDS (0.55) | HPGDSGABRA5USP30ALDH1A1MEN1 | |
| SCHEMBL2071582 | 0.82 | HPGDS (0.57) | HPGDSUSP30MEN1CYP1A2CYP3A4 | |
| SCHEMBL2073405 | 0.81 | HPGDS (0.62) | HPGDSGABRA5USP30ADORA3 | |
| SCHEMBL2073800 | 0.81 | HPGDS (0.56) | HPGDSGABRA5USP30MEN1CYP1A2 | |
| SCHEMBL2070565 | 0.81 | HPGDS (0.63) | HPGDSGABRA5USP30MEN1CYP1A2 | |
| SCHEMBL2070380 | 0.80 | HPGDS (0.60) | HPGDSGABRA5USP30ALDH1A1MEN1 | |
| SCHEMBL2073348 | 0.80 | HPGDS (0.60) | HPGDSGABRA5USP30ALDH1A1LMNA | |
| SCHEMBL2071807 | 0.79 | HPGDS (0.61) | HPGDSGABRA5USP30MEN1CYP1A2 | |
| SCHEMBL2072260 | 0.79 | HPGDS (0.61) | HPGDSGABRA5USP30ALDH1A1MEN1 | |
| SCHEMBL2071446 | 0.79 | HPGDS (0.63) | HPGDSGABRA5USP30PDE10AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902373-B2 | asthma; for treating prostaglandin D2 mediated diseases; e.g. 6-(3-fluorophenyl)-N-[1-(1-methyl-1H-tetrazol-5-yl)piperidin-4-yl]nicotinamide | PFIZER INC (US) | 2011-03-08 | — | — | US | disclosed |
| US-20080146569-A1 | Nicotinamide Derivatives | PFIZER INC. | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146569-A1 | Nicotinamide Derivatives | NNT, NAMPT, NADK | HPGDS 984/4885HTT 3053/4885GABRA5 1998/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.