Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 11/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16245089 | 0.80 | CD274 (0.44) | CD274PDCD1 | |
| SCHEMBL18757368 | 0.80 | ALDH1A1 (0.49) | CD274L3MBTL1TDP1HTR1BSMN1; SMN2 | |
| SCHEMBL30668196 | 0.78 | HTR1B (0.46) | CD274MAPTL3MBTL1MAPK1TDP1 | |
| SCHEMBL19897916 | 0.78 | CD274 (0.39) | CD274MAPTL3MBTL1MAPK1TDP1 | |
| SCHEMBL28960000 | 0.78 | HTR1B (0.46) | CD274MAPTL3MBTL1MAPK1TDP1 | |
| SCHEMBL30394059 | 0.78 | CD274 (0.39) | CD274MAPTL3MBTL1MAPK1TDP1 | |
| SCHEMBL7996100 | 0.76 | HTR1B (0.42) | MAPTL3MBTL1MAPK1TDP1HTR1B | |
| SCHEMBL20739298 | 0.76 | CD274 (0.49) | CD274PDCD1 | |
| SCHEMBL13073739 | 0.76 | ALDH1A1 (0.39) | MAPTL3MBTL1MAPK1TDP1HTR1B | |
| SCHEMBL18729182 | 0.75 | CD274 (0.51) | CD274MAPTL3MBTL1SMN1; SMN2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10392405-B2 | Macrocyclic immunomodulators | CHEMOCENTRYX, INC. (US) | 2019-08-27 | — | — | US | disclosed |
| US-20190048022-A1 | MACROCYCLIC IMMUNOMODULATORS | CHEMOCENTRYX, INC. | 2019-02-14 | — | — | US | disclosed |
| WO-2019032547-A1 | MACROCYCLIC IMMUNOMODULATORS | CHEMOCENTRYX, INC. (US) | 2019-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190048022-A1 | MACROCYCLIC IMMUNOMODULATORS | IL2, IL2RA, C3AR1 | CD274 79/4885MAPT 4782/4885L3MBTL1 2423/4885 |
| US-10392405-B2 | Macrocyclic immunomodulators | IL2, IL2RA, C3AR1 | CD274 79/4885MAPT 4782/4885L3MBTL1 2423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.