Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.49 |
| ▸ | HRH2 | P25021 | 4/20 | 0.49 |
| ▸ | HRH1 | P35367 | 4/20 | 0.49 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24114470 | 1.00 | HRH3 (0.49) | HRH3HRH2HRH1PDCD1CD274 | |
| SCHEMBL20729442 | 0.89 | HTR1A (0.55) | HRH3HRH2HRH1PDCD1CD274 | |
| SCHEMBL20729454 | 0.89 | HRH3 (0.47) | HRH3HRH2HRH1ACHE | |
| SCHEMBL28960041 | 0.82 | PDCD1 (0.49) | HRH3HRH2HRH1PDCD1CD274 | |
| SCHEMBL13552419 | 0.81 | HRH3 (0.49) | HRH3HRH2HRH1PDCD1CD274 | |
| SCHEMBL12717290 | 0.81 | HRH3 (0.49) | HRH3HRH2HRH1PDCD1CD274 | |
| SCHEMBL9921265 | 0.81 | HRH3 (0.49) | HRH3HRH2HRH1PDCD1CD274 | |
| SCHEMBL10059171 | 0.80 | HRH3 (0.48) | HRH3HRH2HRH1PDCD1CD274 | |
| SCHEMBL10059156 | 0.80 | HRH3 (0.48) | HRH3HRH2HRH1PDCD1CD274 | |
| SCHEMBL21310147 | 0.80 | HRH3 (0.34) | HRH3HRH2HRH1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019165043-A2 | INDANE-AMINES AS PD-L1 ANTAGONISTS | CHEMOCENTRYX, INC. (US) | 2019-08-29 | — | — | WO | disclosed |
| WO-2019032547-A1 | MACROCYCLIC IMMUNOMODULATORS | CHEMOCENTRYX, INC. (US) | 2019-02-14 | — | — | WO | disclosed |