Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 8/20 | 0.66 |
| ▸ | NAALAD2 | Q9Y3Q0 | 4/20 | 0.60 |
| ▸ | TTR | P02766 | 1/20 | 0.59 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.53 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | NQO1 | P15559 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12754623 | 0.91 | FTO (0.65) | FTONAALAD2TTRKEAP1JAK2 | |
| SCHEMBL17037385 | 0.90 | FTO (0.66) | FTONAALAD2TTRKEAP1JAK2 | |
| SCHEMBL17956697 | 0.90 | FTO (0.69) | FTONAALAD2TTRKEAP1JAK2 | |
| SCHEMBL18461840 | 0.90 | FTO (0.77) | FTONAALAD2TTRKEAP1JAK2 | |
| SCHEMBL20729847 | 0.90 | FTO (0.66) | FTONAALAD2TTRKEAP1JAK2 | |
| SCHEMBL17589330 | 0.89 | FTO (0.64) | FTONAALAD2TTRKEAP1JAK2 | |
| SCHEMBL29368721 | 0.89 | FTO (0.64) | FTONAALAD2TTRKEAP1JAK2 | |
| SCHEMBL9293647 | 0.89 | FTO (0.64) | FTONAALAD2TTRKEAP1JAK2 | |
| SCHEMBL22863319 | 0.89 | NAALAD2 (0.63) | FTONAALAD2TTRKEAP1JAK2 | |
| SCHEMBL20809317 | 0.89 | FTO (0.70) | FTONAALAD2TTRKEAP1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3665161-B1 | NEW TARGETED CYTOTOXIC RATJADONE DERIVATIVES AND CONJUGATES THEREOF | HELMHOLTZ ZENTRUM INFEKTIONSFORSCHUNG GMBH (DE) | 2023-09-27 | — | — | EP | disclosed |
| WO-2019030284-A1 | NEW TARGETED CYTOTOXIC RATJADONE DERIVATIVES AND CONJUGATES THEREOF | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2019-02-14 | — | — | WO | disclosed |