Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 13/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 12/20 | 0.42 |
| ▸ | XIAP | P98170 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1786172 | 0.79 | PIK3CD (0.65) | PIK3CDPIK3CAPIK3CGPIK3CBXIAP | |
| SCHEMBL12991700 | 0.79 | PIK3CG (0.51) | PIK3CDPIK3CAPIK3CGPIK3CBXIAP | |
| SCHEMBL1885511 | 0.79 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3CGPIK3CBXIAP | |
| SCHEMBL1784761 | 0.79 | PIK3CD (0.68) | PIK3CDPIK3CAPIK3CGPIK3CBCLK1 | |
| SCHEMBL1784745 | 0.79 | PIK3CD (0.57) | PIK3CDPIK3CAPIK3CGPIK3CBCLK1 | |
| SCHEMBL1882046 | 0.78 | PIK3CA (0.43) | PIK3CDPIK3CAPIK3CGPIK3CBXIAP | |
| SCHEMBL571452 | 0.77 | PIK3CA (0.69) | PIK3CDPIK3CAPIK3CGPIK3CBPI4KB | |
| SCHEMBL1787009 | 0.77 | PIK3CD (0.68) | PIK3CDPIK3CAPIK3CGPIK3CBCLK1 | |
| SCHEMBL13525246 | 0.77 | PIK3CD (0.57) | PIK3CDPIK3CAPIK3CGPIK3CBPI4KB | |
| SCHEMBL1889405 | 0.77 | PIK3CA (0.50) | PIK3CDPIK3CAPIK3CGPIK3CBXIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902375-B2 | Antiallergens; antiarthritic agents; psoriasis; inflammatory bowel disorders; Crohn's disease; sepsis ; antiproliferative agents; anticancer agents; transplant rejection; stroke; antidiabetic agents; restenosis | NOVARTIS AG (CH) | 2011-03-08 | — | — | US | disclosed |