SCHEMBL20730205

SCHEMBL20730205

BC(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 5/20 0.40
IDO1 P14902 3/20 0.39
TDO2 P48775 1/20 0.39
CES2 O00748 1/20 0.38
PDE2A O00408 3/20 0.37
MAPT P10636 1/20 0.34
RAPGEF4 Q8WZA2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
AKR1C3 P42330 1/20 0.33
AKR1C2 P52895 1/20 0.33
HTR2A P28223 1/20 0.33
HTR2C P28335 1/20 0.33
HTR2B P41595 1/20 0.33
TACR3 P29371 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17621856 0.82 TACR1 (0.39) TACR1IDO1PDE2AMAPTHTR2A
SCHEMBL437277 0.80 TACR1 (0.42) TACR1IDO1TDO2CES2PDE2A
SCHEMBL18106081 0.78 TACR1 (0.41) TACR1IDO1TDO2CES2PDE2A
SCHEMBL13476400 0.78 TACR1 (0.41) TACR1IDO1TDO2CES2PDE2A
SCHEMBL17994000 0.78 TACR1 (0.41) TACR1IDO1TDO2CES2PDE2A
SCHEMBL1492761 0.76 TACR1 (0.51) TACR1IDO1TDO2CES2PDE2A
SCHEMBL16953807 0.76 TACR1 (0.40) TACR1IDO1TDO2CES2PDE2A
SCHEMBL22065471 0.76 TACR1 (0.40) TACR1IDO1TDO2CES2PDE2A
SCHEMBL1728680 0.76 TACR1 (0.51) TACR1IDO1TDO2CES2PDE2A
SCHEMBL336049 0.76 TACR1 (0.51) TACR1IDO1TDO2CES2PDE2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190047264-A1 LAMINATE AND APPLICATION FOR SAME MITSUI CHEMICALS, INC. (JP) 2019-02-14 US disclosed