Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 10/20 | 0.51 |
| ▸ | IDO1 | P14902 | 4/20 | 0.47 |
| ▸ | TDO2 | P48775 | 2/20 | 0.47 |
| ▸ | PDE2A | O00408 | 1/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.42 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | TACR3 | P29371 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1492761 | 1.00 | TACR1 (0.51) | TACR1IDO1TDO2PDE2ACACNA1F | |
| SCHEMBL6917133 | 1.00 | TACR1 (0.51) | TACR1IDO1TDO2PDE2ACACNA1F | |
| SCHEMBL336049 | 1.00 | TACR1 (0.51) | TACR1IDO1TDO2PDE2ACACNA1F | |
| SCHEMBL7939177 | 1.00 | TACR1 (0.51) | TACR1IDO1TDO2PDE2ACACNA1F | |
| Hydrochloric Acid SCHEMBL4471353 | 0.98 | TACR1 (0.50) | TACR1IDO1TDO2PDE2ACACNA1F | |
| Methane SCHEMBL4258949 | 0.98 | TACR1 (0.50) | TACR1IDO1TDO2PDE2ACACNA1F | |
| Hydrochloric Acid SCHEMBL7170075 | 0.98 | TACR1 (0.50) | TACR1IDO1TDO2PDE2ACACNA1F | |
| Hydrochloric Acid SCHEMBL17439064 | 0.98 | TACR1 (0.50) | TACR1IDO1TDO2PDE2ACACNA1F | |
| SCHEMBL29799650 | 0.88 | TACR1 (0.44) | TACR1IDO1TDO2PDE2ACACNA1F | |
| SCHEMBL29799603 | 0.88 | TACR1 (0.44) | TACR1IDO1TDO2PDE2ACACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114457125-B | Method for synthesizing (R) -1- [3,5-bis (trifluoromethyl) phenyl ] ethylamine by coupling transaminase and alcohol dehydrogenase | 浙江工业大学 | 2024-04-09 | — | — | CN | claimed |
| CN-115215941-A | Nano double-enzyme cascade reactor based on spontaneous isopeptide bond covalent self-assembly | 浙江工业大学 | 2022-10-21 | — | — | CN | claimed |
| CN-118389462-A | Fusion enzyme of alcohol dehydrogenase and transaminase, coding gene, engineering bacteria and application | 江西中医药大学 | 2024-07-26 | — | — | CN | disclosed |
| CN-114457125-B | Method for synthesizing (R) -1- [3,5-bis (trifluoromethyl) phenyl ] ethylamine by coupling transaminase and alcohol dehydrogenase | 浙江工业大学 | 2024-04-09 | — | — | CN | disclosed |
| CN-114457125-B | Method for synthesizing (R) -1- [3,5-bis (trifluoromethyl) phenyl ] ethylamine by coupling transaminase and alcohol dehydrogenase | 浙江工业大学 | 2024-04-09 | — | — | CN | disclosed |
| CN-114457125-B | Method for synthesizing (R) -1- [3,5-bis (trifluoromethyl) phenyl ] ethylamine by coupling transaminase and alcohol dehydrogenase | 浙江工业大学 | 2024-04-09 | — | — | CN | disclosed |
| CN-115215941-A | Nano double-enzyme cascade reactor based on spontaneous isopeptide bond covalent self-assembly | 浙江工业大学 | 2022-10-21 | — | — | CN | disclosed |
| CN-114457125-A | Method for synthesizing (R) -1- [3,5-bis (trifluoromethyl) phenyl ] ethylamine by coupling transaminase and alcohol dehydrogenase | 浙江工业大学 | 2022-05-10 | — | — | CN | disclosed |
| CN-114457125-A | Method for synthesizing (R) -1- [3,5-bis (trifluoromethyl) phenyl ] ethylamine by coupling transaminase and alcohol dehydrogenase | 浙江工业大学 | 2022-05-10 | — | — | CN | disclosed |
| US-20140336377-A1 | ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC. (JP) | 2014-11-13 | — | — | US | disclosed |
| EP-2036881-B1 | METHOD FOR PRODUCING OPTICALLY ACTIVE 1-(FLUORO-, TRIFLUOROMETHYL- OR TRIFLUOROMETHOXY-SUBSTITUTED PHENYL)ALKYLAMINE N-MONOALKYL DERIVATIVE | CENTRAL GLASS CO LTD (JP) | 2013-09-25 | — | — | EP | disclosed |
| US-7985880-B2 | Method for producing optically active 1-(fluoro-, trifluoromethyl- or trifluoromethoxy-substituted phenyl) alkylamine N-monoalkyl derivative | CENTRAL GLASS COMPANY, LIMITED (JP) | 2011-07-26 | — | — | US | disclosed |
| US-20100009961-A1 | DIPEPTIDYL PEPTIDASE-IV INHIBITORS | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2010-01-14 | — | — | US | disclosed |
| US-20090326272-A1 | Method for Producing Optically Active 1-(Fluoro-, Trifluoromethyl- or Trifluoromethoxy-Substituted Phenyl) Alkylamine N-Monoalkyl Derivative | CENTRAL GLASS COMPANY, LIMITED (JP) | 2009-12-31 | — | — | US | disclosed |
| US-7553861-B2 | Dipeptidyl peptidase-IV inhibitors | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2009-06-30 | — | — | US | disclosed |
| EP-2036881-A1 | METHOD FOR PRODUCING OPTICALLY ACTIVE 1-(FLUORO-, TRIFLUOROMETHYL- OR TRIFLUOROMETHOXY-SUBSTITUTED PHENYL)ALKYLAMINE N-MONOALKYL DERIVATIVE | Central Glass Co., Ltd. (JP) | 2009-03-18 | — | — | EP | disclosed |
| US-7368609-B2 | Optically active 1-(fluoro-, trifluoromethyl- or trifluoromethoxy- substituted phenyl)alkylamine N-monoalkyl derivatives and process for producing same | CENTRAL GLASS COMPANY, LIMITED (JP) | 2008-05-06 | — | — | US | disclosed |
| US-20070142670-A1 | Optically active 1-(fluoro-, trifluoromethyl- or trifluoromethoxy- substituted phenyl)alkylamine N-monoalkyl derivatives and process for producing same | CENTRAL GLASS CO., LTD. (JP) | 2007-06-21 | — | — | US | disclosed |
| US-7186865-B2 | Reacting optically active secondary amine with alkylation agent in presence of a base, thereby converting the secondary amine into an optically active tertiary amine and subjecting the tertiary amine to hydrogenolysis, producing the N-monoalkyl derivative; intermediates for drugs, agriculture | CENTRAL GLASS COMPANY, LIMITED (JP) | 2007-03-06 | — | — | US | disclosed |
| US-20040235961-A1 | Optically active 1-(fluoro-, trifluoromethyl-or trifluoromethoxy-substituted phenyl) alkylamine n-monoalkyl derivatives and process for producing same | CENTRAL GLASS COMPANY, LIMITED (JP) | 2004-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326272-A1 | Method for Producing Optically Active 1-(Fluoro-, Trifluoromethyl- or Trifluoromethoxy-Substituted Phenyl) Alkylamine N-Monoalkyl Derivative | NAT1, MAOA, HNMT | TACR1 3349/4885IDO1 232/4885TDO2 164/4885 |
| US-20040235961-A1 | Optically active 1-(fluoro-, trifluoromethyl-or trifluoromethoxy-substituted phenyl) alkylamine n-monoalkyl derivatives and process for producing same | NAT1, PNMT, AFF1 | TACR1 3950/4885IDO1 362/4885TDO2 262/4885 |
| US-20100009961-A1 | DIPEPTIDYL PEPTIDASE-IV INHIBITORS | DPP4, DPP3, DPP7 | TACR1 968/4885IDO1 1179/4885TDO2 2050/4885 |
| US-20140336377-A1 | ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS | SCN2B, SCN1B, SCN2A | TACR1 712/4885IDO1 1074/4885TDO2 1035/4885 |
| US-20070142670-A1 | Optically active 1-(fluoro-, trifluoromethyl- or trifluoromethoxy- substituted phenyl)alkylamine N-monoalkyl derivatives and process for producing same | NAT1, AFF1, PNMT | TACR1 3619/4885IDO1 626/4885TDO2 405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.