Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.81 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.79 |
| ▸ | GAK | O14976 | 2/20 | 0.78 |
| ▸ | ABL1 | P00519 | 2/20 | 0.78 |
| ▸ | LCK | P06239 | 2/20 | 0.78 |
| ▸ | MET | P08581 | 2/20 | 0.78 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.78 |
| ▸ | BLK | P51451 | 2/20 | 0.78 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.78 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.78 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.78 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.78 |
| ▸ | EPHA6 | Q9UF33 | 2/20 | 0.78 |
| ▸ | CIT | O14578 | 1/20 | 0.78 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.78 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.78 |
| ▸ | STK10 | O94804 | 1/20 | 0.78 |
| ▸ | LYN | P07948 | 1/20 | 0.78 |
| ▸ | RET | P07949 | 1/20 | 0.78 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12936091 | 1.00 | EGFR (0.81) | EGFRERBB2GAKABL1LCK | |
| SCHEMBL2073182 | 1.00 | EGFR (0.81) | EGFRERBB2GAKABL1LCK | |
| SCHEMBL2073180 | 1.00 | EGFR (0.81) | EGFRERBB2GAKABL1LCK | |
| SCHEMBL12936094 | 0.97 | EGFR (0.76) | EGFRERBB2GAKABL1LCK | |
| SCHEMBL12936092 | 0.96 | EGFR (0.77) | EGFRERBB2GAKABL1LCK | |
| SCHEMBL12936132 | 0.95 | EGFR (0.82) | EGFRERBB2GAKABL1LCK | |
| SCHEMBL12936122 | 0.94 | EGFR (0.79) | EGFRERBB2GAKABL1LCK | |
| SCHEMBL12936124 | 0.94 | EGFR (0.78) | EGFRERBB2GAKABL1LCK | |
| SCHEMBL12936081 | 0.93 | EGFR (0.73) | EGFRERBB2GAKABL1LCK | |
| SCHEMBL12936083 | 0.93 | EGFR (0.73) | EGFRERBB2GAKABL1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863281-B2 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2011-01-04 | — | — | US | claimed |
| US-20080103161-A1 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR THE PREPARATION THEREOF | HIMMELSBACH FRANK | 2008-05-01 | — | — | US | claimed |
| US-20050159436-A1 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-07-21 | — | — | US | claimed |
| US-20040044014-A1 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-03-04 | — | — | US | claimed |
| US-7863281-B2 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2011-01-04 | — | — | US | disclosed |
| US-7863281-B2 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2011-01-04 | — | — | US | disclosed |
| US-7863281-B2 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2011-01-04 | — | — | US | disclosed |
| US-20080103161-A1 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR THE PREPARATION THEREOF | HIMMELSBACH FRANK | 2008-05-01 | — | — | US | disclosed |
| US-20080103161-A1 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR THE PREPARATION THEREOF | HIMMELSBACH FRANK | 2008-05-01 | — | — | US | disclosed |
| US-20080103161-A1 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR THE PREPARATION THEREOF | HIMMELSBACH FRANK | 2008-05-01 | — | — | US | disclosed |
| US-20050159436-A1 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-07-21 | — | — | US | disclosed |
| US-20040044014-A1 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050159436-A1 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof | RET, CYP11B1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | EGFR 478/4885ERBB2 329/4885GAK 502/4885 |
| US-20040044014-A1 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof | CYP11B1, CYP11B2, AR | EGFR 309/4885ERBB2 208/4885GAK 588/4885 |
| US-20080103161-A1 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR THE PREPARATION THEREOF | RET, CYP11B1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | EGFR 478/4885ERBB2 329/4885GAK 502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.