Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 3/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21863437 | 0.79 | DRD2 (0.41) | DRD2DRD4DRD3TLR8TSHR | |
| SCHEMBL33682 | 0.79 | SMPD3 (0.31) | TLR8TSHRMEN1KMT2AKDM4E | |
| SCHEMBL24729869 | 0.76 | DRD2 (0.40) | DRD2DRD4DRD3TLR8PIK3CA | |
| SCHEMBL23089307 | 0.76 | DRD2 (0.40) | DRD2DRD4DRD3TLR8PIK3CA | |
| SCHEMBL27752780 | 0.76 | PDE4B (0.33) | TLR8MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL20731191 | 0.76 | TLR8 (0.33) | TLR8CYP1A2HTTPOLB | |
| SCHEMBL16252831 | 0.74 | TLR8 (0.61) | TLR8 | |
| SCHEMBL16252869 | 0.74 | SSTR4 (0.43) | DRD2DRD4DRD3TLR8PIK3CA | |
| SCHEMBL23132317 | 0.73 | DRD2 (0.38) | DRD2DRD4DRD3TLR8TSHR | |
| SCHEMBL23109051 | 0.73 | DRD2 (0.50) | DRD2DRD4DRD3TLR8PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033707-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2020-02-13 | — | — | WO | disclosed |
| WO-2019032863-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2019-02-14 | — | — | WO | disclosed |