Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.55 |
| ▸ | GPR88 | Q9GZN0 | 11/20 | 0.40 |
| ▸ | METAP2 | P50579 | 3/20 | 0.39 |
| ▸ | METAP1 | P53582 | 3/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ASPH | Q12797 | 1/20 | 0.37 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23461040 | 0.89 | RIPK1 (0.57) | RIPK1GPR88METAP2METAP1KDM4E | |
| SCHEMBL23461042 | 0.89 | RIPK1 (0.57) | RIPK1GPR88METAP2METAP1KDM4E | |
| SCHEMBL25279162 | 0.89 | RIPK1 (0.57) | RIPK1GPR88METAP2METAP1KDM4E | |
| Hydrochloric Acid SCHEMBL30457769 | 0.87 | RIPK1 (0.56) | RIPK1GPR88METAP2METAP1KDM4E | |
| SCHEMBL26606652 | 0.87 | RIPK1 (0.51) | RIPK1GPR88METAP2METAP1AURKA | |
| SCHEMBL24361065 | 0.86 | RIPK1 (0.50) | RIPK1GPR88METAP2METAP1AURKA | |
| SCHEMBL22308452 | 0.86 | RIPK1 (0.50) | RIPK1GPR88METAP2METAP1AURKA | |
| SCHEMBL12564317 | 0.81 | RIPK1 (0.41) | RIPK1GPR88METAP2METAP1AURKA | |
| SCHEMBL25469177 | 0.78 | RIPK1 (0.54) | RIPK1GPR88METAP2METAP1RPS6KB1 | |
| SCHEMBL23460720 | 0.73 | RIPK1 (0.49) | RIPK1GPR88METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019031614-A1 | ANTIBODY-DRUG CONJUGATES INCLUDING HEMIASTERLIN DERIVATIVE | 大日本住友製薬株式会社 | 2019-02-14 | — | — | WO | disclosed |