Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 16/20 | 0.49 |
| ▸ | CDK8 | P49336 | 16/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20733056 | 0.90 | CCNC (0.49) | CCNCCDK8IGF1RMKNK1MKNK2 | |
| SCHEMBL20732965 | 0.85 | CCNC (0.54) | CCNCCDK8MKNK1MKNK2 | |
| SCHEMBL20732925 | 0.84 | CCNC (0.52) | CCNCCDK8CDK19MKNK1MKNK2 | |
| SCHEMBL20733113 | 0.84 | CCNC (0.51) | CCNCCDK8IGF1RCDK19 | |
| SCHEMBL20732937 | 0.83 | CCNC (0.53) | CCNCCDK8CDK19MKNK1MKNK2 | |
| SCHEMBL20732961 | 0.83 | CCNC (0.52) | CCNCCDK8MKNK1MKNK2 | |
| SCHEMBL20732932 | 0.80 | CCNC (0.57) | CCNCCDK8MKNK1MKNK2 | |
| SCHEMBL20732880 | 0.79 | CCNC (0.52) | CCNCCDK8CDK19MKNK1MKNK2 | |
| SCHEMBL30688363 | 0.76 | IKBKE (0.45) | CCNCCDK8IGF1RCDK19 | |
| SCHEMBL20732991 | 0.76 | CCNC (0.62) | CCNCCDK8CDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111670183-A | Novel heterocyclic compounds as CDK8/19 inhibitors | BIOCAD股份公司 | 2020-09-15 | — | — | CN | claimed |
| EP-3666770-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS CDK8/19 INHIBITORS | Joint Stock Company "Biocad" (RU) | 2020-06-17 | — | — | EP | claimed |
| EP-3666770-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS CDK8/19 INHIBITORS | Joint Stock Company "Biocad" (RU) | 2020-06-17 | — | — | EP | disclosed |
| EP-3666770-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS CDK8/19 INHIBITORS | Joint Stock Company "Biocad" (RU) | 2020-06-17 | — | — | EP | disclosed |
| WO-2019031990-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS CDK8/19 INHIBITORS | ЗАКРЫТОЕ АКЦИОНЕРНОЕ ОБЩЕСТВО "БИОКАД" | 2019-02-14 | — | — | WO | disclosed |