Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 17/20 | 0.51 |
| ▸ | CDK8 | P49336 | 17/20 | 0.51 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.50 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21662611 | 0.92 | IKBKE (0.45) | CCNCCDK8CDK19IGF1RATR | |
| SCHEMBL30688363 | 0.92 | IKBKE (0.45) | CCNCCDK8CDK19IGF1RATR | |
| SCHEMBL21662458 | 0.88 | CCNC (0.47) | CCNCCDK8CDK19ATR | |
| SCHEMBL21662612 | 0.87 | CCNC (0.49) | CCNCCDK8CDK19IGF1R | |
| SCHEMBL30688357 | 0.87 | CCNC (0.49) | CCNCCDK8CDK19IGF1R | |
| SCHEMBL20732927 | 0.85 | CCNC (0.56) | CCNCCDK8CDK19MAP4K4 | |
| SCHEMBL20732964 | 0.84 | CCNC (0.49) | CCNCCDK8CDK19IGF1R | |
| SCHEMBL20732959 | 0.84 | CCNC (0.56) | CCNCCDK8CDK19MAP4K4 | |
| SCHEMBL20732879 | 0.81 | MAP4K4 (0.60) | CCNCCDK8CDK19MAP4K4 | |
| SCHEMBL20732881 | 0.80 | CCNC (0.54) | CCNCCDK8CDK19MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111670183-A | Novel heterocyclic compounds as CDK8/19 inhibitors | BIOCAD股份公司 | 2020-09-15 | — | — | CN | claimed |
| EP-3666770-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS CDK8/19 INHIBITORS | Joint Stock Company "Biocad" (RU) | 2020-06-17 | — | — | EP | claimed |
| EP-3666770-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS CDK8/19 INHIBITORS | Joint Stock Company "Biocad" (RU) | 2020-06-17 | — | — | EP | disclosed |
| EP-3666770-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS CDK8/19 INHIBITORS | Joint Stock Company "Biocad" (RU) | 2020-06-17 | — | — | EP | disclosed |
| WO-2019031990-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS CDK8/19 INHIBITORS | ЗАКРЫТОЕ АКЦИОНЕРНОЕ ОБЩЕСТВО "БИОКАД" | 2019-02-14 | — | — | WO | disclosed |