Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 8/20 | 0.63 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.47 |
| ▸ | SMO | Q99835 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | WNT3A | P56704 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2072480 | 0.98 | HPGDS (0.63) | HPGDSUSP30SMOHDAC3HDAC1 | |
| SCHEMBL2072599 | 0.92 | HPGDS (0.60) | HPGDSUSP30SMOWNT3A | |
| SCHEMBL2071519 | 0.92 | HPGDS (0.62) | HPGDSUSP30SMOHDAC3HDAC1 | |
| SCHEMBL2072329 | 0.91 | HPGDS (0.60) | HPGDSUSP30SMOHDAC3HDAC1 | |
| SCHEMBL2072016 | 0.89 | HPGDS (0.58) | HPGDSUSP30SMOHDAC3HDAC1 | |
| SCHEMBL2070824 | 0.89 | HPGDS (0.67) | HPGDSUSP30SMOHDAC3HDAC1 | |
| SCHEMBL2070533 | 0.89 | HPGDS (0.60) | HPGDSUSP30SMOHDAC3HDAC1 | |
| SCHEMBL2072845 | 0.88 | HPGDS (0.66) | HPGDSUSP30SMOHDAC3HDAC1 | |
| SCHEMBL2072029 | 0.88 | HPGDS (0.65) | HPGDSUSP30SMOHDAC3HDAC1 | |
| SCHEMBL2073957 | 0.85 | HPGDS (0.60) | HPGDSUSP30SMOHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902373-B2 | asthma; for treating prostaglandin D2 mediated diseases; e.g. 6-(3-fluorophenyl)-N-[1-(1-methyl-1H-tetrazol-5-yl)piperidin-4-yl]nicotinamide | PFIZER INC (US) | 2011-03-08 | — | — | US | disclosed |
| US-20080146569-A1 | Nicotinamide Derivatives | PFIZER INC. | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146569-A1 | Nicotinamide Derivatives | NNT, NAMPT, NADK | HPGDS 984/4885USP30 4416/4885SMO 1387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.