Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 1/20 | 0.62 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.62 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | DRD4 | P21917 | 1/20 | 0.58 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20204804 | 0.84 | DRD2 (0.55) | XIAPBIRC2DRD2DRD4NOTUM | |
| SCHEMBL6960678 | 0.84 | DRD2 (0.58) | XIAPBIRC2DRD2DRD4NOTUM | |
| SCHEMBL16301346 | 0.83 | NOTUM (0.51) | XIAPBIRC2DRD2DRD4NOTUM | |
| SCHEMBL27559025 | 0.83 | BRD4 (0.55) | XIAPBIRC2DRD2DRD4NOTUM | |
| SCHEMBL20204801 | 0.82 | DRD2 (0.54) | XIAPBIRC2DRD2DRD4NOTUM | |
| SCHEMBL429841 | 0.82 | NOTUM (0.76) | XIAPBIRC2DRD2DRD4NOTUM | |
| SCHEMBL26691238 | 0.81 | NOTUM (0.55) | XIAPBIRC2DRD2DRD4NOTUM | |
| SCHEMBL22104629 | 0.81 | XIAP (0.64) | XIAPBIRC2NOTUMMAPTTP53 | |
| SCHEMBL13525164 | 0.79 | KDM4E (0.66) | NOTUMMAPTTP53TSHRMEN1 | |
| SCHEMBL5006023 | 0.79 | TSHR (0.75) | NOTUMMAPTTP53TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019032563-A1 | INHIBITORS OF BASE EXCISION REPAIR ACTIVITY AND THERAPEUTIC METHODS BASED THEREON | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2019-02-14 | — | — | WO | disclosed |