Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 6/20 | 0.61 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.61 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24199761 | 1.00 | PRMT5 (0.61) | PRMT5WDR77IRAK4NTRK1 | |
| SCHEMBL22522086 | 0.87 | PRMT5 (0.45) | PRMT5WDR77 | |
| SCHEMBL20721426 | 0.76 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL29391290 | 0.76 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL24134707 | 0.72 | PRMT5 (0.64) | PRMT5WDR77 | |
| SCHEMBL20721402 | 0.71 | PRMT5 (0.69) | PRMT5WDR77 | |
| SCHEMBL29391303 | 0.71 | PRMT5 (0.69) | PRMT5WDR77 | |
| SCHEMBL28438103 | 0.67 | PRMT5 (0.59) | PRMT5WDR77NTRK1 | |
| SCHEMBL20733553 | 0.66 | PRMT5 (0.62) | PRMT5WDR77 | |
| SCHEMBL20721580 | 0.63 | PRMT5 (0.73) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3665179-B1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS INC (US) | 2021-06-09 | — | — | EP | disclosed |
| WO-2020206289-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2020-10-08 | — | — | WO | disclosed |
| WO-2019032859-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2019-02-14 | — | — | WO | disclosed |