SCHEMBL20734858

SCHEMBL20734858

Nc1nc(=O)n(C(S)CO/C=C/O)cc1F

nearest known ligand 0.36

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALB P02768 1/20 0.36
POLG P54098 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12228265 0.69 ALB (0.36) ALB
SCHEMBL19242529 0.68 ALB (0.35) ALB
SCHEMBL10137844 0.68 ADORA2A (0.38) ALB
SCHEMBL12894749 0.66 ALB (0.36) ALB
SCHEMBL12894752 0.65 EP300 (0.33) ALB
SCHEMBL22139347 0.65 ALB (0.36) ALB
SCHEMBL18744107 0.65 EP300 (0.32) ALB
SCHEMBL12741722 0.64 EP300 (0.41) ALB
SCHEMBL22139331 0.63 ALB (0.35) ALB
SCHEMBL12741728 0.63 EP300 (0.41) ALB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200171039-A1 COMBINATIONS AND USES AND TREATMENTS VIIV HEALTHCARE COMPANY 2020-06-04 US disclosed
WO-2019030626-A1 COMBINATIONS AND USES AND TREATMENTS THEREOF VIIV HEALTHCARE COMPANY (US) 2019-02-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200171039-A1 COMBINATIONS AND USES AND TREATMENTS TYMP, DCTD, TPMT ALB 2941/4885POLG 182/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.