Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 8/20 | 0.52 |
| ▸ | KLK5 | Q9Y337 | 7/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.47 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.40 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | STS | P08842 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20735102 | 1.00 | KLK7 (0.52) | KLK7KLK5PRSS1PRSS2PRSS3 | |
| SCHEMBL20734892 | 0.90 | KLK7 (0.51) | KLK7KLK5PRSS1PRSS2PRSS3 | |
| SCHEMBL20734894 | 0.90 | KLK7 (0.51) | KLK7KLK5PRSS1PRSS2PRSS3 | |
| SCHEMBL20735107 | 0.89 | KLK7 (0.57) | KLK7KLK5PRSS1PRSS2PRSS3 | |
| SCHEMBL20735106 | 0.89 | KLK7 (0.57) | KLK7KLK5PRSS1PRSS2PRSS3 | |
| SCHEMBL20734937 | 0.89 | KLK7 (0.46) | KLK7KLK5PRSS1PRSS2PRSS3 | |
| SCHEMBL20734936 | 0.89 | KLK7 (0.46) | KLK7KLK5PRSS1PRSS2PRSS3 | |
| SCHEMBL20734818 | 0.85 | KLK7 (0.47) | KLK7KLK5PRSS1PRSS2PRSS3 | |
| SCHEMBL20734817 | 0.85 | KLK7 (0.47) | KLK7KLK5PRSS1PRSS2PRSS3 | |
| SCHEMBL20734886 | 0.85 | KLK7 (0.48) | KLK7KLK5PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019029273-A1 | 4-OXO-ALKYLATED TETRAMIC ACID COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 北京卓凯生物技术有限公司 | 2019-02-14 | — | — | WO | disclosed |
| WO-2019029274-A1 | 4-OXO-ALKYLATED TETRAMIC ACID COMPOUND AND PREPARATION METHOD THEREFOR | 北京卓凯生物技术有限公司 | 2019-02-14 | — | — | WO | disclosed |