Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.73 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.73 |
| ▸ | IDO1 | P14902 | 4/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | NLN | Q9BYT8 | 2/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2369049 | 0.85 | CYP11B1 (1.00) | CYP11B1CYP11B2IDO1CYP3A4LTA4H | |
| Trifluoroacetic Acid SCHEMBL2074049 | 0.84 | IDO1 (0.70) | CYP11B1CYP11B2IDO1CYP3A4LTA4H | |
| SCHEMBL26265591 | 0.79 | CYP11B1 (0.85) | CYP11B1CYP11B2IDO1CYP3A4LTA4H | |
| Trifluoroacetic Acid SCHEMBL28162943 | 0.78 | HRH4 (0.49) | CYP11B1CYP11B2IDO1CYP3A4LTA4H | |
| SCHEMBL26260218 | 0.77 | CYP11B1 (0.82) | CYP11B1CYP11B2IDO1CYP3A4LTA4H | |
| SCHEMBL20054668 | 0.74 | CYP11B1 (0.77) | CYP11B1CYP11B2IDO1CYP3A4LTA4H | |
| SCHEMBL19397348 | 0.71 | CYP11B1 (0.66) | CYP11B1CYP11B2IDO1CYP3A4LTA4H | |
| SCHEMBL12647442 | 0.70 | CYP11B1 (0.70) | CYP11B1CYP11B2IDO1CYP3A4LTA4H | |
| SCHEMBL12647751 | 0.70 | CYP11B1 (0.70) | CYP11B1CYP11B2IDO1CYP3A4LTA4H | |
| Anthracene SCHEMBL1558998 | 0.70 | CES1 (0.50) | IDO1POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863294-B2 | Heterocycle derivatives as histone deacetylase (HDAC) inhibitors | INSTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-01-04 | — | — | US | disclosed |
| US-20090048228-A1 | Heterocycle Derivatives As Histone Deacetylase (Hdac) Inhibitors | MSD ITALIA S.R.L. (IT) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048228-A1 | Heterocycle Derivatives As Histone Deacetylase (Hdac) Inhibitors | HDAC1, HDAC5, HDAC11 | CYP11B1 567/4885CYP11B2 979/4885IDO1 2451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.