Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL279632 | 0.81 | SMN1; SMN2 (0.46) | SMN1; SMN2NOS1SSTR4GAARAB9A | |
| SCHEMBL12818069 | 0.79 | SMN1; SMN2 (0.50) | SMN1; SMN2NOS1SSTR4GAARAB9A | |
| Ammonia Solution, Strong SCHEMBL28044491 | 0.79 | SMN1; SMN2 (0.44) | SMN1; SMN2NOS1SSTR4GAARAB9A | |
| SCHEMBL22991009 | 0.77 | SMN1; SMN2 (0.43) | SMN1; SMN2NOS1SSTR4GAARAB9A | |
| SCHEMBL441546 | 0.77 | SMN1; SMN2 (0.43) | SMN1; SMN2NOS1SSTR4GAARAB9A | |
| SCHEMBL12128459 | 0.77 | SMN1; SMN2 (0.43) | SMN1; SMN2NOS1SSTR4GAARAB9A | |
| SCHEMBL127885 | 0.77 | SMN1; SMN2 (0.43) | SMN1; SMN2NOS1SSTR4GAARAB9A | |
| SCHEMBL8687634 | 0.77 | PDE4A (0.44) | SMN1; SMN2NOS1SSTR4RAB9ACYP3A4 | |
| SCHEMBL20047420 | 0.76 | CCR4 (0.41) | SMN1; SMN2RAB9AKMT2ANPC1MAPK1 | |
| SCHEMBL131590 | 0.74 | SMN1; SMN2 (0.44) | SMN1; SMN2NOS1SSTR4GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11001575-B1 | Benzolactam compounds as protein kinase inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2021-05-11 | — | — | US | disclosed |
| US-10457669-B2 | Benzolactam compounds as protein kinase inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2019-10-29 | — | — | US | disclosed |
| US-20190047990-A1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2019-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190047990-A1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | MAPK1, ALK, MAP3K1 | SMN1; SMN2 2550/4885NOS1 774/4885SSTR4 3594/4885 |
| US-11001575-B1 | Benzolactam compounds as protein kinase inhibitors | MAPK1, ALK, MAP3K1 | SMN1; SMN2 2671/4885NOS1 787/4885SSTR4 3572/4885 |
| US-10457669-B2 | Benzolactam compounds as protein kinase inhibitors | MAPK1, ALK, MAP3K1 | SMN1; SMN2 2550/4885NOS1 774/4885SSTR4 3594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.