Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL279632 | 0.98 | SMN1; SMN2 (0.46) | SMN1; SMN2NOS1SSTR4GAARAB9A | |
| SCHEMBL12818069 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2NOS1SSTR4GAARAB9A | |
| SCHEMBL127885 | 0.79 | SMN1; SMN2 (0.43) | SMN1; SMN2NOS1SSTR4GAARAB9A | |
| SCHEMBL12128459 | 0.79 | SMN1; SMN2 (0.43) | SMN1; SMN2NOS1SSTR4GAARAB9A | |
| SCHEMBL20738486 | 0.79 | SMN1; SMN2 (0.43) | SMN1; SMN2NOS1SSTR4GAARAB9A | |
| SCHEMBL22991009 | 0.79 | SMN1; SMN2 (0.43) | SMN1; SMN2NOS1SSTR4GAARAB9A | |
| SCHEMBL441546 | 0.79 | SMN1; SMN2 (0.43) | SMN1; SMN2NOS1SSTR4GAARAB9A | |
| SCHEMBL8687634 | 0.79 | PDE4A (0.44) | SMN1; SMN2NOS1SSTR4RAB9ACYP3A4 | |
| SCHEMBL131590 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2NOS1SSTR4GAARAB9A | |
| SCHEMBL21587853 | 0.76 | SMN1; SMN2 (0.40) | SMN1; SMN2NOS1SSTR4GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103118680-B | Heteroaryl carboxamides | HOFFMAN-LA ROCHE LTD. (CH) | 2015-12-16 | — | — | CN | disclosed |