Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK6 | Q00534 | 17/20 | 0.69 |
| ▸ | CCND1 | P24385 | 8/20 | 0.69 |
| ▸ | CDK4 | P11802 | 8/20 | 0.69 |
| ▸ | CCND3 | P30281 | 7/20 | 0.69 |
| ▸ | DYRK2 | Q92630 | 4/20 | 0.66 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.65 |
| ▸ | CDK2 | P24941 | 4/20 | 0.65 |
| ▸ | CDK1 | P06493 | 4/20 | 0.65 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.65 |
| ▸ | PIM1 | P11309 | 2/20 | 0.65 |
| ▸ | CIT | O14578 | 1/20 | 0.65 |
| ▸ | GAK | O14976 | 1/20 | 0.65 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.65 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.65 |
| ▸ | STK16 | O75716 | 1/20 | 0.65 |
| ▸ | CCNK | O75909 | 1/20 | 0.65 |
| ▸ | STK10 | O94804 | 1/20 | 0.65 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24632817 | 0.85 | CDK6 (0.68) | CDK6CCND1CDK4CCND3DYRK2 | |
| SCHEMBL19966543 | 0.85 | CDK6 (0.74) | CDK6CCND1CDK4CCND3DYRK2 | |
| SCHEMBL19966563 | 0.84 | CDK6 (0.68) | CDK6CCND1CDK4CCND3DYRK2 | |
| SCHEMBL20740517 | 0.83 | CDK6 (0.66) | CDK6CCND1CDK4CCND3DYRK2 | |
| SCHEMBL28600816 | 0.81 | CDK6 (1.00) | CDK6CCND1CDK4CCND3DYRK2 | |
| SCHEMBL29896930 | 0.81 | CDK6 (1.00) | CDK6CCND1CDK4CCND3DYRK2 | |
| SCHEMBL29379886 | 0.81 | CDK6 (0.82) | CDK6CCND1CDK4CCND3DYRK2 | |
| SCHEMBL28595830 | 0.81 | CDK6 (0.82) | CDK6CCND1CDK4CCND3DYRK2 | |
| SCHEMBL19966535 | 0.81 | CDK6 (0.68) | CDK6CCND1CDK4CCND3DYRK2 | |
| SCHEMBL24482653 | 0.81 | CDK6 (0.75) | CDK6CCND1CDK4CCND3DYRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3444246-B1 | 2,4-DISUBSTITUTED PYRIMIDINE DERIVATIVE AS CDK INHIBITOR AND USE THEREOF | SHANGHAI XUNHE PHARMACEUTICAL TECH CO LTD (CN) | 2019-11-06 | — | — | EP | disclosed |
| EP-3444246-B1 | 2,4-DISUBSTITUTED PYRIMIDINE DERIVATIVE AS CDK INHIBITOR AND USE THEREOF | SHANGHAI XUNHE PHARMACEUTICAL TECH CO LTD (CN) | 2019-11-06 | — | — | EP | disclosed |
| US-10464927-B2 | 2,4-disubstituted pyrimidines as CDK inhibitors | Shanghai Xunhe Pharmaceutical Technology Co. Ltd. (CN) | 2019-11-05 | — | — | US | disclosed |
| US-10464927-B2 | 2,4-disubstituted pyrimidines as CDK inhibitors | Shanghai Xunhe Pharmaceutical Technology Co. Ltd. (CN) | 2019-11-05 | — | — | US | disclosed |
| US-20190071427-A1 | 2,4-Disubstituted Pyrimidine Derivative as CDK Inhibitor and Use Thereof | CHENGDU JINRUI FOUNDATION BIOTECH CO., LTD. (CN) | 2019-03-07 | — | — | US | disclosed |
| US-20190071427-A1 | 2,4-Disubstituted Pyrimidine Derivative as CDK Inhibitor and Use Thereof | CHENGDU JINRUI FOUNDATION BIOTECH CO., LTD. (CN) | 2019-03-07 | — | — | US | disclosed |
| EP-3444246-A1 | 2,4-DISUBSTITUTED PYRIMIDINE DERIVATIVE AS CDK INHIBITOR AND USE THEREOF | Shanghai Xunhe Pharmaceutical Technology Co., Ltd. (CN) | 2019-02-20 | — | — | EP | disclosed |
| EP-3444246-A1 | 2,4-DISUBSTITUTED PYRIMIDINE DERIVATIVE AS CDK INHIBITOR AND USE THEREOF | Shanghai Xunhe Pharmaceutical Technology Co., Ltd. (CN) | 2019-02-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190071427-A1 | 2,4-Disubstituted Pyrimidine Derivative as CDK Inhibitor and Use Thereof | CDK4, CDK2, CDK6 | CDK6 3/4885CCND1 43/4885CDK4 1/4885 |
| US-10464927-B2 | 2,4-disubstituted pyrimidines as CDK inhibitors | CDK4, CDK2, CDK6 | CDK6 3/4885CCND1 43/4885CDK4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.