Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 12/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | TACR3 | P29371 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 8/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19205350 | 0.83 | RBP4 (0.59) | RBP4CYP2C9CYP2C19MAPK14MEN1 | |
| SCHEMBL19205395 | 0.83 | RBP4 (0.59) | RBP4CYP2C9CYP2C19MAPK14MEN1 | |
| SCHEMBL5207932 | 0.83 | RBP4 (0.52) | RBP4TTRMEN1KMT2A | |
| SCHEMBL20744513 | 0.83 | RBP4 (0.52) | RBP4CYP2C9CYP2C19MAPK14TACR3 | |
| SCHEMBL19205428 | 0.83 | RBP4 (0.57) | RBP4CYP2C9CYP2C19MAPK14MEN1 | |
| SCHEMBL20744476 | 0.83 | RBP4 (0.54) | RBP4 | |
| SCHEMBL25416553 | 0.82 | RBP4 (0.62) | RBP4CYP2C9CYP2C19MAPK14TTR | |
| SCHEMBL30544350 | 0.82 | RBP4 (0.62) | RBP4CYP2C9CYP2C19MAPK14TTR | |
| SCHEMBL19205310 | 0.82 | RBP4 (0.60) | RBP4MEN1KMT2A | |
| SCHEMBL19205454 | 0.80 | RBP4 (0.52) | RBP4CYP2C9CYP2C19MAPK14TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3668877-A1 | INDOLE DERIVATIVES AS HISTONE DEMETHYLASE INHIBITORS | Istituto Europeo di Oncologia S.r.l. (IT) | 2020-06-24 | — | — | EP | disclosed |
| WO-2019034774-A1 | INDOLE DERIVATIVES AS HISTONE DEMETHYLASE INHIBITORS | ISTITUTO EUROPEO DI ONCOLOGIA (IEO) S.R.L. (IT) | 2019-02-21 | — | — | WO | disclosed |