Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.45 |
| ▸ | JAK3 | P52333 | 4/20 | 0.45 |
| ▸ | JAK1 | P23458 | 3/20 | 0.44 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | BTK | Q06187 | 4/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | ADK | P55263 | 3/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 4/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.40 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20754371 | 1.00 | JAK2 (0.45) | JAK2JAK3JAK1RETBTK | |
| SCHEMBL24096712 | 0.88 | RET (0.45) | RETBTKLCKLYNPIK3CD | |
| SCHEMBL20746345 | 0.87 | RET (0.44) | RETBTKLCKLYNPIK3CD | |
| SCHEMBL30321048 | 0.87 | RET (0.52) | JAK2JAK3RETBTKLCK | |
| SCHEMBL24096711 | 0.87 | RET (0.52) | JAK2JAK3RETBTKLCK | |
| SCHEMBL22944055 | 0.87 | RET (0.44) | RETBTKLCKLYNPIK3CD | |
| SCHEMBL20744806 | 0.84 | RET (0.43) | RETBTKLCKLYNPIK3CD | |
| SCHEMBL20744804 | 0.84 | RET (0.43) | RETBTKLCKLYNPIK3CD | |
| SCHEMBL20754240 | 0.84 | BTK (0.44) | JAK3RETBTKLCKLYN | |
| SCHEMBL24005941 | 0.83 | ATG7 (0.48) | RETBTKLCKLYNPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3668875-A1 | CDPK1 INHIBITORS, COMPOSITIONS, AND METHODS RELATED THERETO | Vyera Pharmaceuticals, LLC (US) | 2020-06-24 | — | — | EP | disclosed |
| WO-2019036001-A1 | CDPK1 INHIBITORS, COMPOSITIONS, AND METHODS RELATED THERETO | Vyera Pharmaceuticals, LLC (US) | 2019-02-21 | — | — | WO | disclosed |