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ATG7

Ubiquitin-like modifier-activating enzyme ATG7 · O95352 · ATG7 on Sugi Atlas →

2,911 patent compounds predicted against ATG7, 1,844 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL866533 SCHEMBL866533 0.55 20/20
SCHEMBL866579 SCHEMBL866579 0.55 20/20
SCHEMBL887667 SCHEMBL887667 0.53 20/20
SCHEMBL532323 SCHEMBL532323 0.52 20/20
SCHEMBL1512938 SCHEMBL1512938 0.52 20/20
SCHEMBL6579936 SCHEMBL6579936 0.52 20/20
SCHEMBL1077858 SCHEMBL1077858 0.51 20/20
SCHEMBL866845 SCHEMBL866845 0.51 20/20
SCHEMBL1794350 SCHEMBL1794350 0.63 19/20
SCHEMBL4138320 SCHEMBL4138320 0.62 19/20
SCHEMBL4138325 SCHEMBL4138325 0.62 19/20
SCHEMBL9780402 SCHEMBL9780402 0.58 19/20
SCHEMBL1798206 SCHEMBL1798206 0.56 19/20
SCHEMBL1795247 SCHEMBL1795247 0.55 19/20
SCHEMBL1796949 SCHEMBL1796949 0.54 19/20
SCHEMBL1795315 SCHEMBL1795315 0.52 19/20
SCHEMBL4010074 SCHEMBL4010074 0.52 19/20
SCHEMBL1794779 SCHEMBL1794779 0.51 19/20
SCHEMBL5087918 SCHEMBL5087918 0.51 19/20
SCHEMBL6044690 SCHEMBL6044690 0.51 19/20

Clinical trials — most relevant to ATG7 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Efficacy and Safety of Two Anti-T-lymphocyte Immune Globulin (ATG-F) Induction Regimens in Anew Kidney Transplant Patients PHASE4COMPLETED
Efficacy of Lithium Against Chemotherapy Induced Neutropenia in Breast Cancer Patients PHASE3COMPLETED
FOLFOX/Bevacizumab/Hydroxychloroquine (HCQ) in Colorectal Cancer PHASE1/PHASE2COMPLETED
ATG Individualized Dosing Model in URD-PBSCT. PHASE2RECRUITING
Effects of Cannabidiol (CBD) on the Activation of Autophagy and Inflammation Genes, Functional Consequences in Virologically Controlled HIV-infected Patients PHASE2COMPLETED
Autophagy Inhibition Using Hydrochloroquine in Breast Cancer Patients PHASE2UNKNOWN
HCQ+ADC vs ADC in the Treatment of Advanced Breast Cancer PHASE1/PHASE2UNKNOWN
Clostridium Butyricum in Stenosing Crohn's Desease PHASE1/PHASE2NOT_YET_RECRUITING
Nilotinib in Huntington's Disease PHASE1UNKNOWN
Effects of Lithium Therapy on Blood-based Therapeutic Targets in Parkinson's Disease. PHASE1COMPLETED
Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction EARLY_PHASE1RECRUITING
2-A-Day Study: Twice a Day Meals Study. nanCOMPLETED
Association of Autophagy-related Genes ,LncRNA and SNPs With Colorectal Cancer in Egyptian Population nanCOMPLETED
Fasting, Exercise, and Diet to Activate Autophagy in Depression nanNOT_YET_RECRUITING
Time Course for Fasting-induced Autophagy in Humans nanWITHDRAWN
Diagnostic Potential of UCHL1 in Acute Decompensated Heart Failure nanCOMPLETED
Autophagy Bladder Cancer nanUNKNOWN
Exploring Novel Biomarkers of ICU-AW in Mechanically Ventilated Children at the Molecular Level nanENROLLING_BY_INVITATION
Study on the Correlation Between Alveolar Macrophage-derived Autophagosomes and the Severity of Lung Injury in ARDS nanUNKNOWN
The Role of Fibroblast Activation in Uterine Fibroid nanCOMPLETED
Safety and Tolerability of a Nutritional Formula Designed to Aid in Maintenance of Muscle During Periods of Caloric Restriction in Adults nanNOT_YET_RECRUITING
Effects of Trehalose and Polyphenols in Vasculopathic Patients nanCOMPLETED
Muscle Insulin Resistance in Aging (Mirage) nanACTIVE_NOT_RECRUITING
Cellular Pharmacodynamics of Small Molecules in Lysosomal Storage Disorders nanUNKNOWN
Muscle Wasting in Cancer (MWIC) nanCOMPLETED
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men nanRECRUITING
Autophagy Markers in Endometrial Polyps nanCOMPLETED
Sepsis-damaged Organs-double-markers Identification of Organ Failure Using Fluorescent Nanoparticle Tracking Analysis nanCOMPLETED
Autophagy, Oxidative Stress and Hippo Signaling in Human Aortic Aneurysm nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a ATG7 binder may also engage these)

ProteinNameSimilarity
Q641Y5 — 1.000 Q641Y5 →
Q5ZKY2 — 1.000 Q5ZKY2 →
Q9D906 — 1.000 Q9D906 →
Q642Q1 — 0.979 Q642Q1 →
Q7ZY60 — 0.977 Q7ZY60 →
E9Q4Z2 — 0.976 E9Q4Z2 →
Q02053 — 0.976 Q02053 →
Q28GH3 — 0.976 Q28GH3 →
UBA2 SUMO-activating enzyme subunit 2 0.975 landscape →
Q6IQS6 — 0.975 Q6IQS6 →
Q4V7N2 — 0.975 Q4V7N2 →
Q9ER88 — 0.975 Q9ER88 →
Q5ZJV4 — 0.974 Q5ZJV4 →
P31254 — 0.974 P31254 →
Q5U300 — 0.974 Q5U300 →
AGL Glycogen debranching enzyme 0.974 landscape →
P82922 — 0.973 P82922 →
Q8CIG8 — 0.973 Q8CIG8 →
Q64514 — 0.972 Q64514 →
Q04499 — 0.972 Q04499 →
Q6YXZ7 — 0.972 Q6YXZ7 →
Q94A08 — 0.972 Q94A08 →
Q8N1G2 — 0.972 Q8N1G2 →
Q9Z1F9 — 0.972 Q9Z1F9 →
Q8IYB8 — 0.971 Q8IYB8 →
ACACB Acetyl-CoA carboxylase 2 0.971 landscape →
PRMT5 Protein arginine N-methyltransferase 5 0.971 landscape →
Q2PQH8 — 0.971 Q2PQH8 →
DAP3 Small ribosomal subunit protein mS29 0.971 landscape →
Q8BMF3 — 0.971 Q8BMF3 →