Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.47 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20745730 | 1.00 | MAPT (0.64) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL17069523 | 0.84 | MAPT (0.70) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL17069524 | 0.84 | MAPT (0.70) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL17426063 | 0.84 | MAPT (0.70) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL17426061 | 0.84 | MAPT (0.70) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL27979641 | 0.83 | MAPT (0.68) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL6741206 | 0.83 | MAPT (0.68) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL4048121 | 0.83 | MAPT (0.68) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL6742274 | 0.81 | MAPT (0.66) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL6742277 | 0.81 | MAPT (0.66) | MAPTPDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3668863-A1 | TRICYCLIC COMPOUNDS AS HISTONE METHYL-TRANSFERASE INHIBITORS | Global Blood Therapeutics, Inc. (US) | 2020-06-24 | — | — | EP | disclosed |
| WO-2019036377-A1 | TRICYCLIC COMPOUNDS AS HISTONE METHYL-TRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2019-02-21 | — | — | WO | disclosed |