Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 20/20 | 0.81 |
| ▸ | ATM | Q13315 | 10/20 | 0.81 |
| ▸ | PRKDC | P78527 | 5/20 | 0.81 |
| ▸ | GSK3B | P49841 | 3/20 | 0.81 |
| ▸ | JAK2 | O60674 | 1/20 | 0.81 |
| ▸ | ABL1 | P00519 | 1/20 | 0.81 |
| ▸ | KIT | P10721 | 1/20 | 0.81 |
| ▸ | SERPINA2 | P20848 | 1/20 | 0.81 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.81 |
| ▸ | FLT4 | P35916 | 1/20 | 0.81 |
| ▸ | FLT3 | P36888 | 1/20 | 0.81 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.81 |
| ▸ | MTOR | P42345 | 1/20 | 0.81 |
| ▸ | SYK | P43405 | 1/20 | 0.81 |
| ▸ | GSK3A | P49840 | 1/20 | 0.81 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.81 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.81 |
| ▸ | MERTK | Q12866 | 1/20 | 0.81 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3042259 | 0.90 | ATR (0.78) | ATRATMPRKDCGSK3BJAK2 | |
| Berzosertib SCHEMBL30514080 | 0.90 | ATR (1.00) | ATRATMPRKDCGSK3BJAK2 | |
| Berzosertib SCHEMBL3061890 | 0.90 | ATR (1.00) | ATRATMPRKDCGSK3BJAK2 | |
| SCHEMBL20746772 | 0.87 | ATR (0.82) | ATRATMPRKDCGSK3BJAK2 | |
| SCHEMBL20746733 | 0.86 | ATR (0.60) | ATRATMPRKDCGSK3BJAK2 | |
| SCHEMBL20746745 | 0.85 | ATR (0.82) | ATRATMPRKDCGSK3BJAK2 | |
| SCHEMBL20746773 | 0.85 | ATR (0.81) | ATRATMPRKDCGSK3BJAK2 | |
| Berzosertib SCHEMBL15120027 | 0.85 | ATR (0.90) | ATRATMPRKDCGSK3BJAK2 | |
| Berzosertib SCHEMBL15120037 | 0.85 | ATR (0.90) | ATRATMPRKDCGSK3BJAK2 | |
| Berzosertib SCHEMBL15120024 | 0.84 | ATR (0.86) | ATRATMPRKDCGSK3BJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10822331-B2 | Processes for preparing ATR inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-11-03 | — | — | US | disclosed |
| US-10435397-B2 | — | — | 2019-10-08 | — | — | US | disclosed |
| US-20190202818-A1 | PROCESSES FOR PREPARING ATR INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2019-07-04 | — | — | US | disclosed |
| US-10208027-B2 | Processes for preparing ATR inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10822331-B2 | Processes for preparing ATR inhibitors | ATR, ATRIP, CHEK1 | ATR 1/4885ATM 17/4885PRKDC 21/4885 |
| US-20190202818-A1 | PROCESSES FOR PREPARING ATR INHIBITORS | ATR, ATRIP, CHEK1 | ATR 1/4885ATM 19/4885PRKDC 20/4885 |
| US-10435397-B2 | — | ATR, ATRIP, TBK1 | ATR 1/4885ATM 35/4885PRKDC 22/4885 |
| US-10208027-B2 | Processes for preparing ATR inhibitors | ATR, ATRIP, CHEK1 | ATR 1/4885ATM 19/4885PRKDC 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.