SCHEMBL20748429

SCHEMBL20748429

O=C(NC1CCCC1)C1(O)CCCCCC1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 8/20 0.52
NPC1 O15118 4/20 0.52
SMN1; SMN2 Q16637 4/20 0.52
RAB9A P51151 3/20 0.52
MAPT P10636 2/20 0.52
KDM4E B2RXH2 1/20 0.52
ALDH1A1 P00352 1/20 0.52
CYP3A4 P08684 1/20 0.52
EPHX2 P34913 1/20 0.52
HPGD P15428 1/20 0.50
MMP2 P08253 3/20 0.44
CA12 O43570 2/20 0.44
CA1 P00915 2/20 0.44
CA2 P00918 2/20 0.44
CA9 Q16790 2/20 0.44
MMP8 P22894 1/20 0.44
MMP1 P03956 1/20 0.44
MMP3 P08254 1/20 0.44
MAPK1 P28482 1/20 0.44
DUSP3 P51452 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20748435 1.00 EPHX1 (0.52) EPHX1NPC1SMN1; SMN2RAB9AMAPT
SCHEMBL21984724 0.98 EPHX1 (0.48) EPHX1NPC1SMN1; SMN2RAB9AMAPT
SCHEMBL14748226 0.94 EPHX1 (0.54) EPHX1NPC1SMN1; SMN2RAB9AMAPT
SCHEMBL30673977 0.81 EPHX1 (0.54) EPHX1NPC1SMN1; SMN2RAB9AMAPT
SCHEMBL11857733 0.75 EPHX1 (0.46) EPHX1NPC1SMN1; SMN2RAB9AMAPT
SCHEMBL20194660 0.75 HPGD (0.55) EPHX1NPC1SMN1; SMN2RAB9AMAPT
SCHEMBL24312848 0.73 EPHX1 (0.57) EPHX1EPHX2
SCHEMBL15906230 0.73 EPHX1 (0.50) EPHX1NPC1SMN1; SMN2RAB9AKDM4E
SCHEMBL3400643 0.73 SMYD3 (0.40)
SCHEMBL28524385 0.73 EPHX1 (0.50) EPHX1NPC1SMN1; SMN2RAB9AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3444254-B1 HETEROCYCLIC-SUBSTITUTED PYRIDINOPYRIMIDINONE DERIVATIVE AS CDK INHIBITOR AND USE THEREOF SHANGHAI XUNHE PHARMACEUTICAL TECH CO LTD (CN) 2020-05-13 EP disclosed
EP-3444254-A1 HETEROCYCLIC-SUBSTITUTED PYRIDINOPYRIMIDINONE DERIVATIVE AS CDK INHIBITOR AND USE THEREOF Shanghai Xunhe Pharmaceutical Technology Co., Ltd. (CN) 2019-02-20 EP disclosed