Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17843207 | 0.90 | TSHR (0.38) | TSHRMEN1KMT2AMAPTLMNA | |
| SCHEMBL2000747 | 0.86 | TSHR (0.35) | TSHRMEN1KMT2AMAPTLMNA | |
| SCHEMBL17843213 | 0.81 | TSHR (0.39) | TSHRMEN1KMT2AMAPTLMNA | |
| SCHEMBL1999783 | 0.76 | HSD17B10 (0.36) | TSHRMEN1KMT2AMAPTLMNA | |
| SCHEMBL17843249 | 0.76 | KMT2A (0.42) | TSHRMEN1KMT2AHSD17B10ALDH1A1 | |
| SCHEMBL20859092 | 0.75 | NR1H4 (0.35) | — | |
| SCHEMBL17856073 | 0.75 | RET (0.36) | — | |
| SCHEMBL2002199 | 0.72 | KMT2A (0.41) | MEN1KMT2AMAPTHSD17B10ALDH1A1 | |
| SCHEMBL19900847 | 0.71 | ADORA3 (0.39) | TSHRMEN1KMT2AMAPTLMNA | |
| SCHEMBL2006487 | 0.70 | ADORA3 (0.40) | TSHRMEN1KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233831-B1 | NOVEL FXR (NR1H4) MODULATING COMPOUNDS | GILEAD SCIENCES INC (US) | 2019-02-20 | — | — | EP | disclosed |