Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.47 |
| ▸ | SYK | P43405 | 8/20 | 0.45 |
| ▸ | BCL6 | P41182 | 2/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20752248 | 0.91 | LRRK2 (0.49) | SYKLRRK2 | |
| SCHEMBL19527678 | 0.87 | NPC1 (0.47) | EGFRSYK | |
| SCHEMBL18995066 | 0.80 | EGFR (0.49) | EGFRSYKBCL6NCOR2ITK | |
| SCHEMBL15769550 | 0.79 | EGFR (0.40) | EGFRSYKBCL6 | |
| SCHEMBL20752236 | 0.79 | SYK (0.54) | SYKLRRK2 | |
| SCHEMBL15321097 | 0.77 | EGFR (0.42) | EGFRBCL6ITK | |
| SCHEMBL15321098 | 0.77 | EGFR (0.42) | EGFRBCL6ITK | |
| SCHEMBL19527785 | 0.77 | NPC1 (0.47) | EGFRSYKITK | |
| SCHEMBL20752135 | 0.76 | SYK (0.51) | EGFRSYKLRRK2 | |
| SCHEMBL15769941 | 0.72 | PRKCQ (0.41) | SYKLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928891-B1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2019-02-20 | — | — | EP | disclosed |