Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 17/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20752084 | 0.91 | EGFR (0.47) | LRRK2SYK | |
| SCHEMBL19527678 | 0.82 | NPC1 (0.47) | SYK | |
| SCHEMBL15769941 | 0.78 | PRKCQ (0.41) | LRRK2SYKAURKA | |
| SCHEMBL20752249 | 0.77 | AURKA (0.54) | LRRK2SYKAURKA | |
| SCHEMBL20752184 | 0.75 | SYK (0.55) | LRRK2SYKAURKA | |
| SCHEMBL15769550 | 0.73 | EGFR (0.40) | SYK | |
| SCHEMBL18995066 | 0.73 | EGFR (0.49) | SYK | |
| SCHEMBL20752228 | 0.72 | LRRK2 (0.44) | LRRK2SYK | |
| SCHEMBL15321430 | 0.71 | ALK (0.39) | AURKA | |
| SCHEMBL19527785 | 0.71 | NPC1 (0.47) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928891-B1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2019-02-20 | — | — | EP | disclosed |