Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 16/20 | 0.68 |
| ▸ | ULK1 | O75385 | 2/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20752142 | 0.89 | LRRK2 (0.53) | LRRK2 | |
| SCHEMBL20752230 | 0.88 | LRRK2 (0.52) | LRRK2STK17A | |
| SCHEMBL20752302 | 0.88 | LRRK2 (0.71) | LRRK2ULK1 | |
| SCHEMBL20752295 | 0.86 | LRRK2 (0.51) | LRRK2STK17A | |
| SCHEMBL20752245 | 0.84 | LRRK2 (0.61) | LRRK2STK17A | |
| SCHEMBL20752085 | 0.84 | LRRK2 (0.66) | LRRK2CYP1A2 | |
| SCHEMBL20752196 | 0.84 | LRRK2 (0.49) | LRRK2STK17A | |
| SCHEMBL20752189 | 0.83 | LRRK2 (0.49) | LRRK2CYP1A2 | |
| SCHEMBL20752195 | 0.82 | SYK (0.50) | LRRK2 | |
| SCHEMBL14995649 | 0.81 | LRRK2 (1.00) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928891-B1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2019-02-20 | — | — | EP | disclosed |