Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.49 |
| ▸ | PRKCQ | Q04759 | 6/20 | 0.42 |
| ▸ | SYK | P43405 | 3/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20752142 | 0.88 | LRRK2 (0.53) | LRRK2PRKCQSYKAURKA | |
| SCHEMBL20752230 | 0.87 | LRRK2 (0.52) | LRRK2PRKCQSYKAURKA | |
| SCHEMBL20752241 | 0.87 | LRRK2 (0.50) | LRRK2 | |
| SCHEMBL20752188 | 0.86 | LRRK2 (0.41) | LRRK2PRKCQSYKAURKA | |
| SCHEMBL20752295 | 0.85 | LRRK2 (0.51) | LRRK2PRKCQSYK | |
| SCHEMBL20752250 | 0.85 | LRRK2 (0.47) | LRRK2PRKCQ | |
| SCHEMBL20752196 | 0.83 | LRRK2 (0.49) | LRRK2PRKCQSYKAURKA | |
| SCHEMBL20752159 | 0.83 | LRRK2 (0.68) | LRRK2CYP1A2 | |
| SCHEMBL20752245 | 0.83 | LRRK2 (0.61) | LRRK2PRKCQSYKAURKA | |
| SCHEMBL1740757 | 0.83 | PRKCQ (0.50) | LRRK2PRKCQSYKAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928891-B1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2019-02-20 | — | — | EP | disclosed |