Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 15/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20752086 | 0.90 | LRRK2 (0.39) | LRRK2SYKAURKAPRKCQ | |
| SCHEMBL20752189 | 0.86 | LRRK2 (0.49) | LRRK2SYKAURKAPRKCQ | |
| SCHEMBL20752088 | 0.84 | LRRK2 (0.44) | LRRK2 | |
| SCHEMBL15769534 | 0.82 | PRKCQ (0.41) | LRRK2AURKAPRKCQ | |
| SCHEMBL15769535 | 0.79 | PRKCQ (0.34) | PRKCQGRM5MAPK6 | |
| SCHEMBL20752184 | 0.75 | SYK (0.55) | LRRK2SYKAURKAPRKCQ | |
| SCHEMBL1740757 | 0.74 | PRKCQ (0.50) | LRRK2SYKAURKAPRKCQGRM5 | |
| SCHEMBL20752142 | 0.74 | LRRK2 (0.53) | LRRK2SYKAURKAPRKCQ | |
| SCHEMBL20752241 | 0.74 | LRRK2 (0.50) | LRRK2 | |
| SCHEMBL20752250 | 0.73 | LRRK2 (0.47) | LRRK2PRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928891-B1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2019-02-20 | — | — | EP | disclosed |