Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | F2RL1 | P55085 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7602459 | 0.90 | HTT (0.55) | KDM4EHTTMAPTF2RL1GAA | |
| SCHEMBL20756486 | 0.81 | HTT (0.55) | KDM4EHTTMAPTGAASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL29978709 | 0.81 | HTT (1.00) | KDM4EHTTMAPTF2RL1GAA | |
| SCHEMBL20756890 | 0.81 | HTT (0.46) | KDM4EHTTMAPTF2RL1GAA | |
| Hydrochloric Acid SCHEMBL23043576 | 0.81 | HTT (1.00) | KDM4EHTTMAPTF2RL1GAA | |
| SCHEMBL5716060 | 0.77 | ALDH1A1 (0.56) | KDM4EHTTMAPTF2RL1GAA | |
| SCHEMBL15383528 | 0.77 | KDM4E (0.57) | KDM4EHTTMAPTSMN1; SMN2TP53 | |
| SCHEMBL31145170 | 0.77 | KDM4E (0.57) | KDM4EHTTMAPTSMN1; SMN2TP53 | |
| SCHEMBL28174509 | 0.77 | F2RL1 (0.49) | KDM4EHTTMAPTF2RL1GAA | |
| Hydrochloric Acid SCHEMBL15018127 | 0.76 | ALDH1A1 (0.59) | KDM4EHTTMAPTF2RL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019036377-A1 | TRICYCLIC COMPOUNDS AS HISTONE METHYL-TRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2019-02-21 | — | — | WO | disclosed |