Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20745467 | 0.83 | ALDH1A1 (0.33) | KDM4EHSD17B10TDP1CYP1A2CYP2C9 | |
| SCHEMBL20761352 | 0.81 | ALDH1A1 (0.32) | KDM4EHSD17B10TDP1CYP1A2CYP2C9 | |
| SCHEMBL20758619 | 0.81 | KDM4E (0.35) | KDM4EHSD17B10TDP1CYP1A2CYP2C9 | |
| SCHEMBL24719758 | 0.80 | KDM4E (0.35) | KDM4EHSD17B10TDP1CYP1A2CYP2C9 | |
| SCHEMBL20745521 | 0.79 | KDM4E (0.46) | KDM4EHSD17B10TDP1CYP1A2CYP2C9 | |
| SCHEMBL30119061 | 0.76 | HSD17B10 (0.39) | KDM4EHSD17B10TDP1CYP1A2CYP2C9 | |
| SCHEMBL20745408 | 0.76 | KDM4E (0.33) | KDM4EHSD17B10TDP1CYP1A2CYP2C9 | |
| SCHEMBL20745433 | 0.76 | KDM4E (0.37) | KDM4EHSD17B10TDP1CYP1A2CYP2C9 | |
| SCHEMBL20761543 | 0.75 | SMN1; SMN2 (0.35) | KDM4EHSD17B10TDP1CYP1A2CYP2C9 | |
| SCHEMBL25019817 | 0.75 | KDM4E (0.37) | KDM4EHSD17B10TDP1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3668881-B1 | PYRUVATE KINASE ACTIVATORS FOR USE IN TREATING BLOOD DISORDERS | AGIOS PHARMACEUTICALS INC (US) | 2023-10-04 | — | — | EP | disclosed |
| WO-2019035863-A1 | PYRUVATE KINASE ACTIVATORS FOR USE IN TREATING BLOOD DISORDERS | AGIOS PHARMACEUTICALS, INC. (US) | 2019-02-21 | — | — | WO | disclosed |